Reactivation in working memory: an attractor network model of free recall.

The dynamic nature of human working memory, the general-purpose system for processing continuous input, while keeping no longer externally available information active in the background, is well captured in immediate free recall of supraspan word-lists. Free recall tasks produce several benchmark me...

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Autores principales:	Anders Lansner, Petter Marklund, Sverker Sikström, Lars-Göran Nilsson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b15315dc1106499fb2559dc2d2323406
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spelling	oai:doaj.org-article:b15315dc1106499fb2559dc2d23234062021-11-18T08:57:32ZReactivation in working memory: an attractor network model of free recall.1932-620310.1371/journal.pone.0073776https://doaj.org/article/b15315dc1106499fb2559dc2d23234062013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023690/?tool=EBIhttps://doaj.org/toc/1932-6203The dynamic nature of human working memory, the general-purpose system for processing continuous input, while keeping no longer externally available information active in the background, is well captured in immediate free recall of supraspan word-lists. Free recall tasks produce several benchmark memory phenomena, like the U-shaped serial position curve, reflecting enhanced memory for early and late list items. To account for empirical data, including primacy and recency as well as contiguity effects, we propose here a neurobiologically based neural network model that unifies short- and long-term forms of memory and challenges both the standard view of working memory as persistent activity and dual-store accounts of free recall. Rapidly expressed and volatile synaptic plasticity, modulated intrinsic excitability, and spike-frequency adaptation are suggested as key cellular mechanisms underlying working memory encoding, reactivation and recall. Recent findings on the synaptic and molecular mechanisms behind early LTP and on spiking activity during delayed-match-to-sample tasks support this view.Anders LansnerPetter MarklundSverker SikströmLars-Göran NilssonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e73776 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anders Lansner Petter Marklund Sverker Sikström Lars-Göran Nilsson Reactivation in working memory: an attractor network model of free recall.
description	The dynamic nature of human working memory, the general-purpose system for processing continuous input, while keeping no longer externally available information active in the background, is well captured in immediate free recall of supraspan word-lists. Free recall tasks produce several benchmark memory phenomena, like the U-shaped serial position curve, reflecting enhanced memory for early and late list items. To account for empirical data, including primacy and recency as well as contiguity effects, we propose here a neurobiologically based neural network model that unifies short- and long-term forms of memory and challenges both the standard view of working memory as persistent activity and dual-store accounts of free recall. Rapidly expressed and volatile synaptic plasticity, modulated intrinsic excitability, and spike-frequency adaptation are suggested as key cellular mechanisms underlying working memory encoding, reactivation and recall. Recent findings on the synaptic and molecular mechanisms behind early LTP and on spiking activity during delayed-match-to-sample tasks support this view.
format	article
author	Anders Lansner Petter Marklund Sverker Sikström Lars-Göran Nilsson
author_facet	Anders Lansner Petter Marklund Sverker Sikström Lars-Göran Nilsson
author_sort	Anders Lansner
title	Reactivation in working memory: an attractor network model of free recall.
title_short	Reactivation in working memory: an attractor network model of free recall.
title_full	Reactivation in working memory: an attractor network model of free recall.
title_fullStr	Reactivation in working memory: an attractor network model of free recall.
title_full_unstemmed	Reactivation in working memory: an attractor network model of free recall.
title_sort	reactivation in working memory: an attractor network model of free recall.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/b15315dc1106499fb2559dc2d2323406
work_keys_str_mv	AT anderslansner reactivationinworkingmemoryanattractornetworkmodeloffreerecall AT pettermarklund reactivationinworkingmemoryanattractornetworkmodeloffreerecall AT sverkersikstrom reactivationinworkingmemoryanattractornetworkmodeloffreerecall AT larsgorannilsson reactivationinworkingmemoryanattractornetworkmodeloffreerecall
_version_	1718421103796289536

Reactivation in working memory: an attractor network model of free recall.

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