Association of high myopia with peripapillary retinal nerve fiber layer in patients with hypertension.
<h4>Purpose</h4>To identify the impacts of hypertension (HTN), high myopia, and the combination thereof on peripapillary retinal nerve fiber layer (pRNFL) thickness.<h4>Methods</h4>All subjects were divided into four groups: control (group 1); patients with HTN without high m...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/b15480a4a84047f180cee7310f724966 |
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| Sumario: | <h4>Purpose</h4>To identify the impacts of hypertension (HTN), high myopia, and the combination thereof on peripapillary retinal nerve fiber layer (pRNFL) thickness.<h4>Methods</h4>All subjects were divided into four groups: control (group 1); patients with HTN without high myopia (group 2); patients with high myopia without HTN (group 3); and patients with both HTN and high myopia (group 4). The pRNFL thicknesses were compared using a one-way analysis of variance. Univariate and multivariate linear regression analyses were used to identify factors affecting pRNFL thickness in subjects with and without HTN.<h4>Results</h4>The mean pRNFL thicknesses were 93.9±8.8, 88.7±6.8, 86.4±8.1, and 82.5±9.6 μm in group 1, 2, 3, and 4, respectively, and differed significantly (P<0.001). On multivariate linear regression analyses, age (β = -0.181, P = 0.044), axial length (β = -1.491, P<0.001), and HTN (β = -4.876, P = 0.044) significantly affected pRNFL thickness. Additionally, age and axial length affected the pRNFL thickness in subjects with HTN (age, β = -0.254, P = 0.020; axial length, β = -1.608, P<0.001) much more than in subjects without HTN (age, β = -0.028, P = 0.712; axial length, β = -1.324, P<0.001).<h4>Conclusions</h4>High myopia and HTN affected pRNFL reduction and a combination of the 2 diseases exacerbated pRNFL damage. This could be a confounding factor in interpreting pRNFL thickness in patients with ophthalmic diseases affecting the pRNFL thickness when combined with the 2 diseases. |
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