Association of high myopia with peripapillary retinal nerve fiber layer in patients with hypertension.

<h4>Purpose</h4>To identify the impacts of hypertension (HTN), high myopia, and the combination thereof on peripapillary retinal nerve fiber layer (pRNFL) thickness.<h4>Methods</h4>All subjects were divided into four groups: control (group 1); patients with HTN without high m...

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Autores principales:	Min-Woo Lee, Hyung-Bin Lim, Hyung-Moon Koo, Young-Hoon Lee, Jung-Yeul Kim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b15480a4a84047f180cee7310f724966
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spelling	oai:doaj.org-article:b15480a4a84047f180cee7310f7249662021-12-02T20:18:07ZAssociation of high myopia with peripapillary retinal nerve fiber layer in patients with hypertension.1932-620310.1371/journal.pone.0256131https://doaj.org/article/b15480a4a84047f180cee7310f7249662021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256131https://doaj.org/toc/1932-6203<h4>Purpose</h4>To identify the impacts of hypertension (HTN), high myopia, and the combination thereof on peripapillary retinal nerve fiber layer (pRNFL) thickness.<h4>Methods</h4>All subjects were divided into four groups: control (group 1); patients with HTN without high myopia (group 2); patients with high myopia without HTN (group 3); and patients with both HTN and high myopia (group 4). The pRNFL thicknesses were compared using a one-way analysis of variance. Univariate and multivariate linear regression analyses were used to identify factors affecting pRNFL thickness in subjects with and without HTN.<h4>Results</h4>The mean pRNFL thicknesses were 93.9±8.8, 88.7±6.8, 86.4±8.1, and 82.5±9.6 μm in group 1, 2, 3, and 4, respectively, and differed significantly (P<0.001). On multivariate linear regression analyses, age (β = -0.181, P = 0.044), axial length (β = -1.491, P<0.001), and HTN (β = -4.876, P = 0.044) significantly affected pRNFL thickness. Additionally, age and axial length affected the pRNFL thickness in subjects with HTN (age, β = -0.254, P = 0.020; axial length, β = -1.608, P<0.001) much more than in subjects without HTN (age, β = -0.028, P = 0.712; axial length, β = -1.324, P<0.001).<h4>Conclusions</h4>High myopia and HTN affected pRNFL reduction and a combination of the 2 diseases exacerbated pRNFL damage. This could be a confounding factor in interpreting pRNFL thickness in patients with ophthalmic diseases affecting the pRNFL thickness when combined with the 2 diseases.Min-Woo LeeHyung-Bin LimHyung-Moon KooYoung-Hoon LeeJung-Yeul KimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256131 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Min-Woo Lee Hyung-Bin Lim Hyung-Moon Koo Young-Hoon Lee Jung-Yeul Kim Association of high myopia with peripapillary retinal nerve fiber layer in patients with hypertension.
description	<h4>Purpose</h4>To identify the impacts of hypertension (HTN), high myopia, and the combination thereof on peripapillary retinal nerve fiber layer (pRNFL) thickness.<h4>Methods</h4>All subjects were divided into four groups: control (group 1); patients with HTN without high myopia (group 2); patients with high myopia without HTN (group 3); and patients with both HTN and high myopia (group 4). The pRNFL thicknesses were compared using a one-way analysis of variance. Univariate and multivariate linear regression analyses were used to identify factors affecting pRNFL thickness in subjects with and without HTN.<h4>Results</h4>The mean pRNFL thicknesses were 93.9±8.8, 88.7±6.8, 86.4±8.1, and 82.5±9.6 μm in group 1, 2, 3, and 4, respectively, and differed significantly (P<0.001). On multivariate linear regression analyses, age (β = -0.181, P = 0.044), axial length (β = -1.491, P<0.001), and HTN (β = -4.876, P = 0.044) significantly affected pRNFL thickness. Additionally, age and axial length affected the pRNFL thickness in subjects with HTN (age, β = -0.254, P = 0.020; axial length, β = -1.608, P<0.001) much more than in subjects without HTN (age, β = -0.028, P = 0.712; axial length, β = -1.324, P<0.001).<h4>Conclusions</h4>High myopia and HTN affected pRNFL reduction and a combination of the 2 diseases exacerbated pRNFL damage. This could be a confounding factor in interpreting pRNFL thickness in patients with ophthalmic diseases affecting the pRNFL thickness when combined with the 2 diseases.
format	article
author	Min-Woo Lee Hyung-Bin Lim Hyung-Moon Koo Young-Hoon Lee Jung-Yeul Kim
author_facet	Min-Woo Lee Hyung-Bin Lim Hyung-Moon Koo Young-Hoon Lee Jung-Yeul Kim
author_sort	Min-Woo Lee
title	Association of high myopia with peripapillary retinal nerve fiber layer in patients with hypertension.
title_short	Association of high myopia with peripapillary retinal nerve fiber layer in patients with hypertension.
title_full	Association of high myopia with peripapillary retinal nerve fiber layer in patients with hypertension.
title_fullStr	Association of high myopia with peripapillary retinal nerve fiber layer in patients with hypertension.
title_full_unstemmed	Association of high myopia with peripapillary retinal nerve fiber layer in patients with hypertension.
title_sort	association of high myopia with peripapillary retinal nerve fiber layer in patients with hypertension.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b15480a4a84047f180cee7310f724966
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Association of high myopia with peripapillary retinal nerve fiber layer in patients with hypertension.

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