Uncovering the SUMOylation and ubiquitylation crosstalk in human cells using sequential peptide immunopurification

Ubiquitylation and SUMOylation are two important related post-translational modifications. Here the authors present an approach for the simultaneous identification and quantification of protein-wide SUMO and ubiquitin sites from a single sample, uncovering widespread crosstalk between the two modifi...

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Autores principales: Frédéric Lamoliatte, Francis P. McManus, Ghizlane Maarifi, Mounira K. Chelbi-Alix, Pierre Thibault
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/b154cff5cc4243dfbe1fb2ed128260a0
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Sumario:Ubiquitylation and SUMOylation are two important related post-translational modifications. Here the authors present an approach for the simultaneous identification and quantification of protein-wide SUMO and ubiquitin sites from a single sample, uncovering widespread crosstalk between the two modifications.