NTS Targeted By miR-182 Modulates the Apoptosis of Goat Endometrial Epithelial Cells

Neurotensin is a tridecapeptide that functions in prenatal metabolism. It is targeted and downregulated by miR-182 through binding the seed site of miR-182 to the 3′ untranslated region and reduced by a candidate tumor suppressor, testin. Considering that apoptosis is critical in the development of...

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Autores principales:	Xiaopeng An, Yue Zhang, Jidan Liu, Xingna Ma, Zhaoyu Guo, Binyun Cao
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2019
Materias:	mirna neurotensin testin apoptosis Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/b1582cb7b59147d4b2c561f4d54fc7f6
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id	oai:doaj.org-article:b1582cb7b59147d4b2c561f4d54fc7f6
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spelling	oai:doaj.org-article:b1582cb7b59147d4b2c561f4d54fc7f62021-11-17T21:27:53ZNTS Targeted By miR-182 Modulates the Apoptosis of Goat Endometrial Epithelial Cells1820-744810.2478/acve-2019-0028https://doaj.org/article/b1582cb7b59147d4b2c561f4d54fc7f62019-09-01T00:00:00Zhttps://doi.org/10.2478/acve-2019-0028https://doaj.org/toc/1820-7448Neurotensin is a tridecapeptide that functions in prenatal metabolism. It is targeted and downregulated by miR-182 through binding the seed site of miR-182 to the 3′ untranslated region and reduced by a candidate tumor suppressor, testin. Considering that apoptosis is critical in the development of mammalian preattachment embryos, this study investigated the modulation of neurotensin to the apoptosis of goat endometrial epithelial cells and apoptosis-related proteins (P38 MAPK and caspase8). Results showed that Neurotensin resisted the apoptosis of goat endometrial epithelial cells through the caspase8 pathway and activated the phosphorylation of P38 MAPK, which is involved in blastocyst formation. Thus, miR-182 is likely to promote uterus health by targeting Neurotensin and upregulating Testin.Xiaopeng AnYue ZhangJidan LiuXingna MaZhaoyu GuoBinyun CaoSciendoarticlemirnaneurotensintestinapoptosisVeterinary medicineSF600-1100ENActa Veterinaria, Vol 69, Iss 3, Pp 340-347 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	mirna neurotensin testin apoptosis Veterinary medicine SF600-1100
spellingShingle	mirna neurotensin testin apoptosis Veterinary medicine SF600-1100 Xiaopeng An Yue Zhang Jidan Liu Xingna Ma Zhaoyu Guo Binyun Cao NTS Targeted By miR-182 Modulates the Apoptosis of Goat Endometrial Epithelial Cells
description	Neurotensin is a tridecapeptide that functions in prenatal metabolism. It is targeted and downregulated by miR-182 through binding the seed site of miR-182 to the 3′ untranslated region and reduced by a candidate tumor suppressor, testin. Considering that apoptosis is critical in the development of mammalian preattachment embryos, this study investigated the modulation of neurotensin to the apoptosis of goat endometrial epithelial cells and apoptosis-related proteins (P38 MAPK and caspase8). Results showed that Neurotensin resisted the apoptosis of goat endometrial epithelial cells through the caspase8 pathway and activated the phosphorylation of P38 MAPK, which is involved in blastocyst formation. Thus, miR-182 is likely to promote uterus health by targeting Neurotensin and upregulating Testin.
format	article
author	Xiaopeng An Yue Zhang Jidan Liu Xingna Ma Zhaoyu Guo Binyun Cao
author_facet	Xiaopeng An Yue Zhang Jidan Liu Xingna Ma Zhaoyu Guo Binyun Cao
author_sort	Xiaopeng An
title	NTS Targeted By miR-182 Modulates the Apoptosis of Goat Endometrial Epithelial Cells
title_short	NTS Targeted By miR-182 Modulates the Apoptosis of Goat Endometrial Epithelial Cells
title_full	NTS Targeted By miR-182 Modulates the Apoptosis of Goat Endometrial Epithelial Cells
title_fullStr	NTS Targeted By miR-182 Modulates the Apoptosis of Goat Endometrial Epithelial Cells
title_full_unstemmed	NTS Targeted By miR-182 Modulates the Apoptosis of Goat Endometrial Epithelial Cells
title_sort	nts targeted by mir-182 modulates the apoptosis of goat endometrial epithelial cells
publisher	Sciendo
publishDate	2019
url	https://doaj.org/article/b1582cb7b59147d4b2c561f4d54fc7f6
work_keys_str_mv	AT xiaopengan ntstargetedbymir182modulatestheapoptosisofgoatendometrialepithelialcells AT yuezhang ntstargetedbymir182modulatestheapoptosisofgoatendometrialepithelialcells AT jidanliu ntstargetedbymir182modulatestheapoptosisofgoatendometrialepithelialcells AT xingnama ntstargetedbymir182modulatestheapoptosisofgoatendometrialepithelialcells AT zhaoyuguo ntstargetedbymir182modulatestheapoptosisofgoatendometrialepithelialcells AT binyuncao ntstargetedbymir182modulatestheapoptosisofgoatendometrialepithelialcells
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NTS Targeted By miR-182 Modulates the Apoptosis of Goat Endometrial Epithelial Cells

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