Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity

The lipid composition of the plasma membrane defines the localisation of KRAS and its oncogenic function. Here the authors show that EFR3A binds to active KRAS to recruit PI4KA and alters the lipid composition of the plasma membrane to promote KRAS oncogenic signalling and tumorigenesis.

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Autores principales:	Hema Adhikari, Walaa E. Kattan, Shivesh Kumar, Pei Zhou, John F. Hancock, Christopher M. Counter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b15aa2d411704499ade6c2c0e8aff6f3
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spelling	oai:doaj.org-article:b15aa2d411704499ade6c2c0e8aff6f32021-12-02T17:19:41ZOncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity10.1038/s41467-021-25523-52041-1723https://doaj.org/article/b15aa2d411704499ade6c2c0e8aff6f32021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25523-5https://doaj.org/toc/2041-1723The lipid composition of the plasma membrane defines the localisation of KRAS and its oncogenic function. Here the authors show that EFR3A binds to active KRAS to recruit PI4KA and alters the lipid composition of the plasma membrane to promote KRAS oncogenic signalling and tumorigenesis.Hema AdhikariWalaa E. KattanShivesh KumarPei ZhouJohn F. HancockChristopher M. CounterNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hema Adhikari Walaa E. Kattan Shivesh Kumar Pei Zhou John F. Hancock Christopher M. Counter Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity
description	The lipid composition of the plasma membrane defines the localisation of KRAS and its oncogenic function. Here the authors show that EFR3A binds to active KRAS to recruit PI4KA and alters the lipid composition of the plasma membrane to promote KRAS oncogenic signalling and tumorigenesis.
format	article
author	Hema Adhikari Walaa E. Kattan Shivesh Kumar Pei Zhou John F. Hancock Christopher M. Counter
author_facet	Hema Adhikari Walaa E. Kattan Shivesh Kumar Pei Zhou John F. Hancock Christopher M. Counter
author_sort	Hema Adhikari
title	Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity
title_short	Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity
title_full	Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity
title_fullStr	Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity
title_full_unstemmed	Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity
title_sort	oncogenic kras is dependent upon an efr3a-pi4ka signaling axis for potent tumorigenic activity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b15aa2d411704499ade6c2c0e8aff6f3
work_keys_str_mv	AT hemaadhikari oncogenickrasisdependentuponanefr3api4kasignalingaxisforpotenttumorigenicactivity AT walaaekattan oncogenickrasisdependentuponanefr3api4kasignalingaxisforpotenttumorigenicactivity AT shiveshkumar oncogenickrasisdependentuponanefr3api4kasignalingaxisforpotenttumorigenicactivity AT peizhou oncogenickrasisdependentuponanefr3api4kasignalingaxisforpotenttumorigenicactivity AT johnfhancock oncogenickrasisdependentuponanefr3api4kasignalingaxisforpotenttumorigenicactivity AT christophermcounter oncogenickrasisdependentuponanefr3api4kasignalingaxisforpotenttumorigenicactivity
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Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity

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