Is pentraxin 3 level an effective biomarker in disease activity in patients with rheumatoid arthritis?

Introduction The aim of the current study was to identify whether serum pentraxin 3 (PTX3) level could be a marker of increased inflammation in rheumatoid arthritis (RA) patients. Material and methods The study included 41 patients diagnosed with RA according to the American College of Rheumatology...

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Autores principales:	Ozlem Balbaloglu, Seda Sabah Ozcan
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	rheumatoid arthritis disease activity pentraxin3 pentraxin 3 Medicine R
Acceso en línea:	https://doaj.org/article/b15ac59f1e4e43aaa4d95a9021dcac2a
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spelling	oai:doaj.org-article:b15ac59f1e4e43aaa4d95a9021dcac2a2021-12-02T18:33:05ZIs pentraxin 3 level an effective biomarker in disease activity in patients with rheumatoid arthritis?1734-19221896-915110.5114/aoms.2017.69726https://doaj.org/article/b15ac59f1e4e43aaa4d95a9021dcac2a2019-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Is-pentraxin-3-level-an-effective-biomarker-in-disease-activity-in-patients-with,75899,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction The aim of the current study was to identify whether serum pentraxin 3 (PTX3) level could be a marker of increased inflammation in rheumatoid arthritis (RA) patients. Material and methods The study included 41 patients diagnosed with RA according to the American College of Rheumatology (ACR) 1990 diagnostic criteria. We compared the serum PTX3 levels between RA patients and a healthy control group, the relationship between PTX3 level and disease activity was also examined. Results A statistically significant difference was determined between the RA patients and controls as regards PTX3, platelets, C-reactive protein, and mean platelet volume results (p = 0.042, p = 0.007, p = 0.017, p < 0.001, respectively). There was no statistically significant difference in terms of PTX3 level between anti-CCP-positive and -negative patients (p = 0.368). No statistically significant difference was determined in respect of PTX3 levels between RA patients with different disease activity scores (p = 0.346). Conclusions No relationship was determined between PTX3 and disease activity in RA patients, nor with traditional clinical and biochemical measurements of disease activity. However, the PTX3 levels of the RA patients were found to be high in comparison with the control group. Because, from these results, the role of PTX3 in the pathogenesis of RA cannot be ignored, there is a need for further studies to determine the potential role of PTX3 in RA pathogenesis.Ozlem BalbalogluSeda Sabah OzcanTermedia Publishing Housearticlerheumatoid arthritisdisease activitypentraxin3pentraxin 3MedicineRENArchives of Medical Science, Vol 16, Iss 1, Pp 81-86 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	rheumatoid arthritis disease activity pentraxin3 pentraxin 3 Medicine R
spellingShingle	rheumatoid arthritis disease activity pentraxin3 pentraxin 3 Medicine R Ozlem Balbaloglu Seda Sabah Ozcan Is pentraxin 3 level an effective biomarker in disease activity in patients with rheumatoid arthritis?
description	Introduction The aim of the current study was to identify whether serum pentraxin 3 (PTX3) level could be a marker of increased inflammation in rheumatoid arthritis (RA) patients. Material and methods The study included 41 patients diagnosed with RA according to the American College of Rheumatology (ACR) 1990 diagnostic criteria. We compared the serum PTX3 levels between RA patients and a healthy control group, the relationship between PTX3 level and disease activity was also examined. Results A statistically significant difference was determined between the RA patients and controls as regards PTX3, platelets, C-reactive protein, and mean platelet volume results (p = 0.042, p = 0.007, p = 0.017, p < 0.001, respectively). There was no statistically significant difference in terms of PTX3 level between anti-CCP-positive and -negative patients (p = 0.368). No statistically significant difference was determined in respect of PTX3 levels between RA patients with different disease activity scores (p = 0.346). Conclusions No relationship was determined between PTX3 and disease activity in RA patients, nor with traditional clinical and biochemical measurements of disease activity. However, the PTX3 levels of the RA patients were found to be high in comparison with the control group. Because, from these results, the role of PTX3 in the pathogenesis of RA cannot be ignored, there is a need for further studies to determine the potential role of PTX3 in RA pathogenesis.
format	article
author	Ozlem Balbaloglu Seda Sabah Ozcan
author_facet	Ozlem Balbaloglu Seda Sabah Ozcan
author_sort	Ozlem Balbaloglu
title	Is pentraxin 3 level an effective biomarker in disease activity in patients with rheumatoid arthritis?
title_short	Is pentraxin 3 level an effective biomarker in disease activity in patients with rheumatoid arthritis?
title_full	Is pentraxin 3 level an effective biomarker in disease activity in patients with rheumatoid arthritis?
title_fullStr	Is pentraxin 3 level an effective biomarker in disease activity in patients with rheumatoid arthritis?
title_full_unstemmed	Is pentraxin 3 level an effective biomarker in disease activity in patients with rheumatoid arthritis?
title_sort	is pentraxin 3 level an effective biomarker in disease activity in patients with rheumatoid arthritis?
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/b15ac59f1e4e43aaa4d95a9021dcac2a
work_keys_str_mv	AT ozlembalbaloglu ispentraxin3levelaneffectivebiomarkerindiseaseactivityinpatientswithrheumatoidarthritis AT sedasabahozcan ispentraxin3levelaneffectivebiomarkerindiseaseactivityinpatientswithrheumatoidarthritis
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Is pentraxin 3 level an effective biomarker in disease activity in patients with rheumatoid arthritis?

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