Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors

Transplantation of healthy photoreceptor cells has been shown to rescue blindness. Here, the authors show that rather than donor cells integrating into the host retina, the predominant mechanism underlying this rescue involves exchange of cytoplasmic material between donor and host cells in vivo.

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Autores principales:	R. A. Pearson, A. Gonzalez-Cordero, E. L. West, J. R. Ribeiro, N. Aghaizu, D. Goh, R. D. Sampson, A. Georgiadis, P. V. Waldron, Y. Duran, A. Naeem, M. Kloc, E. Cristante, K. Kruczek, K. Warre-Cornish, J. C. Sowden, A. J. Smith, R. R. Ali
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b15e33f7b89f4b918a0a570c180b0b86
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spelling	oai:doaj.org-article:b15e33f7b89f4b918a0a570c180b0b862021-12-02T14:39:15ZDonor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors10.1038/ncomms130292041-1723https://doaj.org/article/b15e33f7b89f4b918a0a570c180b0b862016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13029https://doaj.org/toc/2041-1723Transplantation of healthy photoreceptor cells has been shown to rescue blindness. Here, the authors show that rather than donor cells integrating into the host retina, the predominant mechanism underlying this rescue involves exchange of cytoplasmic material between donor and host cells in vivo.R. A. PearsonA. Gonzalez-CorderoE. L. WestJ. R. RibeiroN. AghaizuD. GohR. D. SampsonA. GeorgiadisP. V. WaldronY. DuranA. NaeemM. KlocE. CristanteK. KruczekK. Warre-CornishJ. C. SowdenA. J. SmithR. R. AliNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q R. A. Pearson A. Gonzalez-Cordero E. L. West J. R. Ribeiro N. Aghaizu D. Goh R. D. Sampson A. Georgiadis P. V. Waldron Y. Duran A. Naeem M. Kloc E. Cristante K. Kruczek K. Warre-Cornish J. C. Sowden A. J. Smith R. R. Ali Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors
description	Transplantation of healthy photoreceptor cells has been shown to rescue blindness. Here, the authors show that rather than donor cells integrating into the host retina, the predominant mechanism underlying this rescue involves exchange of cytoplasmic material between donor and host cells in vivo.
format	article
author	R. A. Pearson A. Gonzalez-Cordero E. L. West J. R. Ribeiro N. Aghaizu D. Goh R. D. Sampson A. Georgiadis P. V. Waldron Y. Duran A. Naeem M. Kloc E. Cristante K. Kruczek K. Warre-Cornish J. C. Sowden A. J. Smith R. R. Ali
author_facet	R. A. Pearson A. Gonzalez-Cordero E. L. West J. R. Ribeiro N. Aghaizu D. Goh R. D. Sampson A. Georgiadis P. V. Waldron Y. Duran A. Naeem M. Kloc E. Cristante K. Kruczek K. Warre-Cornish J. C. Sowden A. J. Smith R. R. Ali
author_sort	R. A. Pearson
title	Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors
title_short	Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors
title_full	Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors
title_fullStr	Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors
title_full_unstemmed	Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors
title_sort	donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b15e33f7b89f4b918a0a570c180b0b86
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Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors

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