The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams

Abstract Pregnant women with polycystic ovary syndrome (PCOS) are often overweight or obese. To study the effects of maternal androgen excess in obese dams on metabolism, placental function and fetal growth, female C57Bl6J mice were fed a control (CD) or a high fat/high sucrose (HF/HS) diet for 4–10...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Romina Fornes, Manuel Maliqueo, Min Hu, Laila Hadi, Juan M. Jimenez-Andrade, Kerstin Ebefors, Jenny Nyström, Fernand Labrie, Thomas Jansson, Anna Benrick, Elisabet Stener-Victorin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b161fbd5a3d943858e76b3a8477c2c0c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b161fbd5a3d943858e76b3a8477c2c0c
record_format	dspace
spelling	oai:doaj.org-article:b161fbd5a3d943858e76b3a8477c2c0c2021-12-02T11:52:38ZThe effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams10.1038/s41598-017-08559-w2045-2322https://doaj.org/article/b161fbd5a3d943858e76b3a8477c2c0c2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08559-whttps://doaj.org/toc/2045-2322Abstract Pregnant women with polycystic ovary syndrome (PCOS) are often overweight or obese. To study the effects of maternal androgen excess in obese dams on metabolism, placental function and fetal growth, female C57Bl6J mice were fed a control (CD) or a high fat/high sucrose (HF/HS) diet for 4–10 weeks, and then mated. On gestational day (GD) 15.5–17.5, dams were injected with dihydrotestosterone (CD-DHT, HF/HS-DHT) or a vehicle (CD-Veh, HF/HS-Veh). HF/HS dams had higher fat content, both before mating and on GD18.5, with no difference in glucose homeostasis, whereas the insulin sensitivity was higher in DHT-exposed dams. Compared to the CD groups, the livers from HF/HS dams weighed more on GD18.5, the triglyceride content was higher, and there was a dysregulation of liver enzymes related to lipogenesis and higher mRNA expression of Fitm1. Fetuses from HF/HS-Veh dams had lower liver triglyceride content and mRNA expression of Srebf1c. Maternal DHT exposure, regardless of diet, decreased fetal liver Pparg mRNA expression and increased placental androgen receptor protein expression. Maternal diet-induced obesity, together with androgen excess, affects maternal and fetal liver function as demonstrated by increased triglyceride content and dysfunctional expression of enzymes and transcription factors involved in de novo lipogenesis and fat storage.Romina FornesManuel MaliqueoMin HuLaila HadiJuan M. Jimenez-AndradeKerstin EbeforsJenny NyströmFernand LabrieThomas JanssonAnna BenrickElisabet Stener-VictorinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Romina Fornes Manuel Maliqueo Min Hu Laila Hadi Juan M. Jimenez-Andrade Kerstin Ebefors Jenny Nyström Fernand Labrie Thomas Jansson Anna Benrick Elisabet Stener-Victorin The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams
description	Abstract Pregnant women with polycystic ovary syndrome (PCOS) are often overweight or obese. To study the effects of maternal androgen excess in obese dams on metabolism, placental function and fetal growth, female C57Bl6J mice were fed a control (CD) or a high fat/high sucrose (HF/HS) diet for 4–10 weeks, and then mated. On gestational day (GD) 15.5–17.5, dams were injected with dihydrotestosterone (CD-DHT, HF/HS-DHT) or a vehicle (CD-Veh, HF/HS-Veh). HF/HS dams had higher fat content, both before mating and on GD18.5, with no difference in glucose homeostasis, whereas the insulin sensitivity was higher in DHT-exposed dams. Compared to the CD groups, the livers from HF/HS dams weighed more on GD18.5, the triglyceride content was higher, and there was a dysregulation of liver enzymes related to lipogenesis and higher mRNA expression of Fitm1. Fetuses from HF/HS-Veh dams had lower liver triglyceride content and mRNA expression of Srebf1c. Maternal DHT exposure, regardless of diet, decreased fetal liver Pparg mRNA expression and increased placental androgen receptor protein expression. Maternal diet-induced obesity, together with androgen excess, affects maternal and fetal liver function as demonstrated by increased triglyceride content and dysfunctional expression of enzymes and transcription factors involved in de novo lipogenesis and fat storage.
format	article
author	Romina Fornes Manuel Maliqueo Min Hu Laila Hadi Juan M. Jimenez-Andrade Kerstin Ebefors Jenny Nyström Fernand Labrie Thomas Jansson Anna Benrick Elisabet Stener-Victorin
author_facet	Romina Fornes Manuel Maliqueo Min Hu Laila Hadi Juan M. Jimenez-Andrade Kerstin Ebefors Jenny Nyström Fernand Labrie Thomas Jansson Anna Benrick Elisabet Stener-Victorin
author_sort	Romina Fornes
title	The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams
title_short	The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams
title_full	The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams
title_fullStr	The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams
title_full_unstemmed	The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams
title_sort	effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b161fbd5a3d943858e76b3a8477c2c0c
work_keys_str_mv	AT rominafornes theeffectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT manuelmaliqueo theeffectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT minhu theeffectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT lailahadi theeffectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT juanmjimenezandrade theeffectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT kerstinebefors theeffectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT jennynystrom theeffectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT fernandlabrie theeffectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT thomasjansson theeffectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT annabenrick theeffectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT elisabetstenervictorin theeffectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT rominafornes effectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT manuelmaliqueo effectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT minhu effectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT lailahadi effectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT juanmjimenezandrade effectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT kerstinebefors effectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT jennynystrom effectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT fernandlabrie effectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT thomasjansson effectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT annabenrick effectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams AT elisabetstenervictorin effectofandrogenexcessonmaternalmetabolismplacentalfunctionandfetalgrowthinobesedams
_version_	1718395005519790080

The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams

Ejemplares similares