N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

Liver metastasis of colorectal cancer leads to poor prognosis. Here the authors report that an N 6-methyladenosine modified circular RNA is upregulated in colorectal cancer and promotes liver metastasis by enhancing the stability of HMGA2 mRNA.

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Autores principales:	Ri-Xin Chen, Xin Chen, Liang-Ping Xia, Jia-Xing Zhang, Zhi-Zhong Pan, Xiao-Dan Ma, Kai Han, Jie-Wei Chen, Jean-Gabrie Judde, Olivier Deas, Feng Wang, Ning-Fang Ma, Xinyuan Guan, Jing-Ping Yun, Feng-Wei Wang, Rui-Hua Xu, Dan Xie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b165c50eadf6469b96c3526cdacb8a2b
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spelling	oai:doaj.org-article:b165c50eadf6469b96c3526cdacb8a2b2021-12-02T14:39:16ZN 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis10.1038/s41467-019-12651-22041-1723https://doaj.org/article/b165c50eadf6469b96c3526cdacb8a2b2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12651-2https://doaj.org/toc/2041-1723Liver metastasis of colorectal cancer leads to poor prognosis. Here the authors report that an N 6-methyladenosine modified circular RNA is upregulated in colorectal cancer and promotes liver metastasis by enhancing the stability of HMGA2 mRNA.Ri-Xin ChenXin ChenLiang-Ping XiaJia-Xing ZhangZhi-Zhong PanXiao-Dan MaKai HanJie-Wei ChenJean-Gabrie JuddeOlivier DeasFeng WangNing-Fang MaXinyuan GuanJing-Ping YunFeng-Wei WangRui-Hua XuDan XieNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ri-Xin Chen Xin Chen Liang-Ping Xia Jia-Xing Zhang Zhi-Zhong Pan Xiao-Dan Ma Kai Han Jie-Wei Chen Jean-Gabrie Judde Olivier Deas Feng Wang Ning-Fang Ma Xinyuan Guan Jing-Ping Yun Feng-Wei Wang Rui-Hua Xu Dan Xie N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis
description	Liver metastasis of colorectal cancer leads to poor prognosis. Here the authors report that an N 6-methyladenosine modified circular RNA is upregulated in colorectal cancer and promotes liver metastasis by enhancing the stability of HMGA2 mRNA.
format	article
author	Ri-Xin Chen Xin Chen Liang-Ping Xia Jia-Xing Zhang Zhi-Zhong Pan Xiao-Dan Ma Kai Han Jie-Wei Chen Jean-Gabrie Judde Olivier Deas Feng Wang Ning-Fang Ma Xinyuan Guan Jing-Ping Yun Feng-Wei Wang Rui-Hua Xu Dan Xie
author_facet	Ri-Xin Chen Xin Chen Liang-Ping Xia Jia-Xing Zhang Zhi-Zhong Pan Xiao-Dan Ma Kai Han Jie-Wei Chen Jean-Gabrie Judde Olivier Deas Feng Wang Ning-Fang Ma Xinyuan Guan Jing-Ping Yun Feng-Wei Wang Rui-Hua Xu Dan Xie
author_sort	Ri-Xin Chen
title	N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis
title_short	N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis
title_full	N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis
title_fullStr	N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis
title_full_unstemmed	N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis
title_sort	n 6-methyladenosine modification of circnsun2 facilitates cytoplasmic export and stabilizes hmga2 to promote colorectal liver metastasis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b165c50eadf6469b96c3526cdacb8a2b
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N 6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

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