Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma

Neural stem cells have a tropism for glioblastoma. Here the authors employ fibroblasts directly reprogrammed into induced neural stem cells and loaded with cytotoxic molecules to migrate to xenotransplanted brain tumours in mice, achieving tumour shrinkage and prolonged survival.

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Autores principales:	Juli R. Bagó, Adolfo Alfonso-Pecchio, Onyi Okolie, Raluca Dumitru, Amanda Rinkenbaugh, Albert S. Baldwin, C. Ryan Miller, Scott T. Magness, Shawn D. Hingtgen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b167638618f64960906efb2752744934
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spelling	oai:doaj.org-article:b167638618f64960906efb27527449342021-12-02T17:32:21ZTherapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma10.1038/ncomms105932041-1723https://doaj.org/article/b167638618f64960906efb27527449342016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10593https://doaj.org/toc/2041-1723Neural stem cells have a tropism for glioblastoma. Here the authors employ fibroblasts directly reprogrammed into induced neural stem cells and loaded with cytotoxic molecules to migrate to xenotransplanted brain tumours in mice, achieving tumour shrinkage and prolonged survival.Juli R. BagóAdolfo Alfonso-PecchioOnyi OkolieRaluca DumitruAmanda RinkenbaughAlbert S. BaldwinC. Ryan MillerScott T. MagnessShawn D. HingtgenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Juli R. Bagó Adolfo Alfonso-Pecchio Onyi Okolie Raluca Dumitru Amanda Rinkenbaugh Albert S. Baldwin C. Ryan Miller Scott T. Magness Shawn D. Hingtgen Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma
description	Neural stem cells have a tropism for glioblastoma. Here the authors employ fibroblasts directly reprogrammed into induced neural stem cells and loaded with cytotoxic molecules to migrate to xenotransplanted brain tumours in mice, achieving tumour shrinkage and prolonged survival.
format	article
author	Juli R. Bagó Adolfo Alfonso-Pecchio Onyi Okolie Raluca Dumitru Amanda Rinkenbaugh Albert S. Baldwin C. Ryan Miller Scott T. Magness Shawn D. Hingtgen
author_facet	Juli R. Bagó Adolfo Alfonso-Pecchio Onyi Okolie Raluca Dumitru Amanda Rinkenbaugh Albert S. Baldwin C. Ryan Miller Scott T. Magness Shawn D. Hingtgen
author_sort	Juli R. Bagó
title	Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma
title_short	Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma
title_full	Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma
title_fullStr	Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma
title_full_unstemmed	Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma
title_sort	therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b167638618f64960906efb2752744934
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Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma

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