T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders

Abstract We performed integrative analysis of genes associated with type 2 Diabetes Mellitus (T2DM) associated complications by automated text mining with manual curation and also gene expression analysis from Gene Expression Omnibus. They were analysed for pathogenic or protective role, trends, int...

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Autores principales:	Jyoti Rani, Inna Mittal, Atreyi Pramanik, Namita Singh, Namita Dube, Smriti Sharma, Bhanwar Lal Puniya, Muthukurussi Varieth Raghunandanan, Ahmed Mobeen, Srinivasan Ramachandran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b17054815de84c198fd29687644cc43d
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spelling	oai:doaj.org-article:b17054815de84c198fd29687644cc43d2021-12-02T16:06:38ZT2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders10.1038/s41598-017-07238-02045-2322https://doaj.org/article/b17054815de84c198fd29687644cc43d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07238-0https://doaj.org/toc/2045-2322Abstract We performed integrative analysis of genes associated with type 2 Diabetes Mellitus (T2DM) associated complications by automated text mining with manual curation and also gene expression analysis from Gene Expression Omnibus. They were analysed for pathogenic or protective role, trends, interaction with risk factors, Gene Ontology enrichment and tissue wise differential expression. The database T2DiACoD houses 650 genes, and 34 microRNAs associated with T2DM complications. Seven genes AGER, TNFRSF11B, CRK, PON1, ADIPOQ, CRP and NOS3 are associated with all 5 complications. Several genes are studied in multiple years in all complications with high proportion in cardiovascular (75.8%) and atherosclerosis (51.3%). T2DM Patients’ skeletal muscle tissues showed high fold change in differentially expressed genes. Among the differentially expressed genes, VEGFA is associated with several complications of T2DM. A few genes ACE2, ADCYAP1, HDAC4, NCF1, NFE2L2, OSM, SMAD1, TGFB1, BDNF, SYVN1, TXNIP, CD36, CYP2J2, NLRP3 with details of protective role are catalogued. Obesity is clearly a dominant risk factor interacting with the genes of T2DM complications followed by inflammation, diet and stress to variable extents. This information emerging from the integrative approach used in this work could benefit further therapeutic approaches. The T2DiACoD is available at www.http://t2diacod.igib.res.in/ .Jyoti RaniInna MittalAtreyi PramanikNamita SinghNamita DubeSmriti SharmaBhanwar Lal PuniyaMuthukurussi Varieth RaghunandananAhmed MobeenSrinivasan RamachandranNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-21 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jyoti Rani Inna Mittal Atreyi Pramanik Namita Singh Namita Dube Smriti Sharma Bhanwar Lal Puniya Muthukurussi Varieth Raghunandanan Ahmed Mobeen Srinivasan Ramachandran T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders
description	Abstract We performed integrative analysis of genes associated with type 2 Diabetes Mellitus (T2DM) associated complications by automated text mining with manual curation and also gene expression analysis from Gene Expression Omnibus. They were analysed for pathogenic or protective role, trends, interaction with risk factors, Gene Ontology enrichment and tissue wise differential expression. The database T2DiACoD houses 650 genes, and 34 microRNAs associated with T2DM complications. Seven genes AGER, TNFRSF11B, CRK, PON1, ADIPOQ, CRP and NOS3 are associated with all 5 complications. Several genes are studied in multiple years in all complications with high proportion in cardiovascular (75.8%) and atherosclerosis (51.3%). T2DM Patients’ skeletal muscle tissues showed high fold change in differentially expressed genes. Among the differentially expressed genes, VEGFA is associated with several complications of T2DM. A few genes ACE2, ADCYAP1, HDAC4, NCF1, NFE2L2, OSM, SMAD1, TGFB1, BDNF, SYVN1, TXNIP, CD36, CYP2J2, NLRP3 with details of protective role are catalogued. Obesity is clearly a dominant risk factor interacting with the genes of T2DM complications followed by inflammation, diet and stress to variable extents. This information emerging from the integrative approach used in this work could benefit further therapeutic approaches. The T2DiACoD is available at www.http://t2diacod.igib.res.in/ .
format	article
author	Jyoti Rani Inna Mittal Atreyi Pramanik Namita Singh Namita Dube Smriti Sharma Bhanwar Lal Puniya Muthukurussi Varieth Raghunandanan Ahmed Mobeen Srinivasan Ramachandran
author_facet	Jyoti Rani Inna Mittal Atreyi Pramanik Namita Singh Namita Dube Smriti Sharma Bhanwar Lal Puniya Muthukurussi Varieth Raghunandanan Ahmed Mobeen Srinivasan Ramachandran
author_sort	Jyoti Rani
title	T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders
title_short	T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders
title_full	T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders
title_fullStr	T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders
title_full_unstemmed	T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders
title_sort	t2diacod: a gene atlas of type 2 diabetes mellitus associated complex disorders
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b17054815de84c198fd29687644cc43d
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T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders

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