Cystic fibrosis swine fail to secrete airway surface liquid in response to inhalation of pathogens

Cystic fibrosis is caused by mutations in the CFTR chloride channel, leading to reduced airway surface liquid secretion. Here the authors show that exposure to bacteria triggers secretion in wild-type but not in pig models of cystic fibrosis, suggesting an impaired response to pathogens contributes...

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Autores principales:	Xiaojie Luan, George Belev, Julian S. Tam, Santosh Jagadeeshan, Noman Hassan, Paula Gioino, Nikolay Grishchenko, Yanyun Huang, James L. Carmalt, Tanya Duke, Teela Jones, Bev Monson, Monique Burmester, Tomer Simovich, Orhan Yilmaz, Veronica A. Campanucci, Terry E. Machen, L. Dean Chapman, Juan P. Ianowski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b1726fa086ae482099aa7acc7f31f83b
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spelling	oai:doaj.org-article:b1726fa086ae482099aa7acc7f31f83b2021-12-02T14:41:22ZCystic fibrosis swine fail to secrete airway surface liquid in response to inhalation of pathogens10.1038/s41467-017-00835-72041-1723https://doaj.org/article/b1726fa086ae482099aa7acc7f31f83b2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00835-7https://doaj.org/toc/2041-1723Cystic fibrosis is caused by mutations in the CFTR chloride channel, leading to reduced airway surface liquid secretion. Here the authors show that exposure to bacteria triggers secretion in wild-type but not in pig models of cystic fibrosis, suggesting an impaired response to pathogens contributes to infection.Xiaojie LuanGeorge BelevJulian S. TamSantosh JagadeeshanNoman HassanPaula GioinoNikolay GrishchenkoYanyun HuangJames L. CarmaltTanya DukeTeela JonesBev MonsonMonique BurmesterTomer SimovichOrhan YilmazVeronica A. CampanucciTerry E. MachenL. Dean ChapmanJuan P. IanowskiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaojie Luan George Belev Julian S. Tam Santosh Jagadeeshan Noman Hassan Paula Gioino Nikolay Grishchenko Yanyun Huang James L. Carmalt Tanya Duke Teela Jones Bev Monson Monique Burmester Tomer Simovich Orhan Yilmaz Veronica A. Campanucci Terry E. Machen L. Dean Chapman Juan P. Ianowski Cystic fibrosis swine fail to secrete airway surface liquid in response to inhalation of pathogens
description	Cystic fibrosis is caused by mutations in the CFTR chloride channel, leading to reduced airway surface liquid secretion. Here the authors show that exposure to bacteria triggers secretion in wild-type but not in pig models of cystic fibrosis, suggesting an impaired response to pathogens contributes to infection.
format	article
author	Xiaojie Luan George Belev Julian S. Tam Santosh Jagadeeshan Noman Hassan Paula Gioino Nikolay Grishchenko Yanyun Huang James L. Carmalt Tanya Duke Teela Jones Bev Monson Monique Burmester Tomer Simovich Orhan Yilmaz Veronica A. Campanucci Terry E. Machen L. Dean Chapman Juan P. Ianowski
author_facet	Xiaojie Luan George Belev Julian S. Tam Santosh Jagadeeshan Noman Hassan Paula Gioino Nikolay Grishchenko Yanyun Huang James L. Carmalt Tanya Duke Teela Jones Bev Monson Monique Burmester Tomer Simovich Orhan Yilmaz Veronica A. Campanucci Terry E. Machen L. Dean Chapman Juan P. Ianowski
author_sort	Xiaojie Luan
title	Cystic fibrosis swine fail to secrete airway surface liquid in response to inhalation of pathogens
title_short	Cystic fibrosis swine fail to secrete airway surface liquid in response to inhalation of pathogens
title_full	Cystic fibrosis swine fail to secrete airway surface liquid in response to inhalation of pathogens
title_fullStr	Cystic fibrosis swine fail to secrete airway surface liquid in response to inhalation of pathogens
title_full_unstemmed	Cystic fibrosis swine fail to secrete airway surface liquid in response to inhalation of pathogens
title_sort	cystic fibrosis swine fail to secrete airway surface liquid in response to inhalation of pathogens
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b1726fa086ae482099aa7acc7f31f83b
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Cystic fibrosis swine fail to secrete airway surface liquid in response to inhalation of pathogens

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