The protease GtgE from Salmonella exclusively targets inactive Rab GTPases

The protease GtgE from Salmonella exclusively targets inactive Rab GTPases

The bacterial protease GtgE is involved in the establishment of Salmonellosis. Here the authors provide a structural and biochemical analysis of GtgE that sheds light on the molecular mechanisms of reprogramming infected host cells via site-specific proteolytic cleavage of the vesicular trafficking...

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Autores principales: Rudolf Wachtel, Bastian Bräuning, Sophie L. Mader, Felix Ecker, Ville R. I. Kaila, Michael Groll, Aymelt Itzen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/b1737a5a57314d0189c7e7ac298e8846
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spelling oai:doaj.org-article:b1737a5a57314d0189c7e7ac298e88462021-12-02T14:40:54ZThe protease GtgE from Salmonella exclusively targets inactive Rab GTPases10.1038/s41467-017-02110-12041-1723https://doaj.org/article/b1737a5a57314d0189c7e7ac298e88462018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02110-1https://doaj.org/toc/2041-1723The bacterial protease GtgE is involved in the establishment of Salmonellosis. Here the authors provide a structural and biochemical analysis of GtgE that sheds light on the molecular mechanisms of reprogramming infected host cells via site-specific proteolytic cleavage of the vesicular trafficking regulator Rab32.Rudolf WachtelBastian BräuningSophie L. MaderFelix EckerVille R. I. KailaMichael GrollAymelt ItzenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Rudolf Wachtel
Bastian Bräuning
Sophie L. Mader
Felix Ecker
Ville R. I. Kaila
Michael Groll
Aymelt Itzen
The protease GtgE from Salmonella exclusively targets inactive Rab GTPases
description The bacterial protease GtgE is involved in the establishment of Salmonellosis. Here the authors provide a structural and biochemical analysis of GtgE that sheds light on the molecular mechanisms of reprogramming infected host cells via site-specific proteolytic cleavage of the vesicular trafficking regulator Rab32.
format article
author Rudolf Wachtel
Bastian Bräuning
Sophie L. Mader
Felix Ecker
Ville R. I. Kaila
Michael Groll
Aymelt Itzen
author_facet Rudolf Wachtel
Bastian Bräuning
Sophie L. Mader
Felix Ecker
Ville R. I. Kaila
Michael Groll
Aymelt Itzen
author_sort Rudolf Wachtel
title The protease GtgE from Salmonella exclusively targets inactive Rab GTPases
title_short The protease GtgE from Salmonella exclusively targets inactive Rab GTPases
title_full The protease GtgE from Salmonella exclusively targets inactive Rab GTPases
title_fullStr The protease GtgE from Salmonella exclusively targets inactive Rab GTPases
title_full_unstemmed The protease GtgE from Salmonella exclusively targets inactive Rab GTPases
title_sort protease gtge from salmonella exclusively targets inactive rab gtpases
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/b1737a5a57314d0189c7e7ac298e8846
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