Extramotor damage is associated with cognition in primary lateral sclerosis patients.

<h4>Objectives</h4>This is a cross-sectional study aimed at investigating cognitive performances in patients with primary lateral sclerosis (PLS) and using diffusion tensor (DT) magnetic resonance imaging (MRI) to determine the topographical distribution of microstructural white matter (...

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Autores principales:	Elisa Canu, Federica Agosta, Sebastiano Galantucci, Adriano Chiò, Nilo Riva, Vincenzo Silani, Andrea Falini, Giancarlo Comi, Massimo Filippi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b175141d8cbf49a1b461ce7fae973621
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spelling	oai:doaj.org-article:b175141d8cbf49a1b461ce7fae9736212021-11-18T08:43:14ZExtramotor damage is associated with cognition in primary lateral sclerosis patients.1932-620310.1371/journal.pone.0082017https://doaj.org/article/b175141d8cbf49a1b461ce7fae9736212013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24349172/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>This is a cross-sectional study aimed at investigating cognitive performances in patients with primary lateral sclerosis (PLS) and using diffusion tensor (DT) magnetic resonance imaging (MRI) to determine the topographical distribution of microstructural white matter (WM) damage in patients with or without cognitive deficits.<h4>Methods</h4>DT MRI scans were obtained from 21 PLS patients and 35 age- and sex-matched healthy controls. All PLS patients underwent a comprehensive neuropsychological battery. Tract-based-spatial-statistics (TBSS) was used to perform a whole-brain voxel-wise analysis of fractional anisotropy (FA), axial, radial (radD) and mean diffusivity (MD).<h4>Results</h4>Ten PLS patients had abnormal scores in at least one neuropsychological test (PLS with cognitive deficits, PLS-cd). Compared with healthy controls and cognitively unimpaired PLS patients (PLS-cu), PLS-cd cases showed decreased FA and increased MD and radD in the corticospinal tract (CST), corpus callosum, brainstem, anterior limb of internal capsule, superior and inferior longitudinal fasciculi, fornix, thalamic radiations, and parietal lobes, bilaterally. Compared with healthy controls, PLS-cd patients showed further decreased FA and increased radD in the cerebellar WM, bilaterally. Compared with controls, PLS-cu patients showed decreased FA in the mid-body of corpus callosum. In PLS, executive and language test scores correlated with WM damage.<h4>Conclusions</h4>This is the first study evaluating the relationship between cognitive performance and WM tract damage in PLS patients. PLS can be associated with a multi-domain cognitive impairment. WM damage to interhemispheric, limbic and major associative WM tracts seem to be the structural correlate of cognitive abnormalities in these patients.Elisa CanuFederica AgostaSebastiano GalantucciAdriano ChiòNilo RivaVincenzo SilaniAndrea FaliniGiancarlo ComiMassimo FilippiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e82017 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elisa Canu Federica Agosta Sebastiano Galantucci Adriano Chiò Nilo Riva Vincenzo Silani Andrea Falini Giancarlo Comi Massimo Filippi Extramotor damage is associated with cognition in primary lateral sclerosis patients.
description	<h4>Objectives</h4>This is a cross-sectional study aimed at investigating cognitive performances in patients with primary lateral sclerosis (PLS) and using diffusion tensor (DT) magnetic resonance imaging (MRI) to determine the topographical distribution of microstructural white matter (WM) damage in patients with or without cognitive deficits.<h4>Methods</h4>DT MRI scans were obtained from 21 PLS patients and 35 age- and sex-matched healthy controls. All PLS patients underwent a comprehensive neuropsychological battery. Tract-based-spatial-statistics (TBSS) was used to perform a whole-brain voxel-wise analysis of fractional anisotropy (FA), axial, radial (radD) and mean diffusivity (MD).<h4>Results</h4>Ten PLS patients had abnormal scores in at least one neuropsychological test (PLS with cognitive deficits, PLS-cd). Compared with healthy controls and cognitively unimpaired PLS patients (PLS-cu), PLS-cd cases showed decreased FA and increased MD and radD in the corticospinal tract (CST), corpus callosum, brainstem, anterior limb of internal capsule, superior and inferior longitudinal fasciculi, fornix, thalamic radiations, and parietal lobes, bilaterally. Compared with healthy controls, PLS-cd patients showed further decreased FA and increased radD in the cerebellar WM, bilaterally. Compared with controls, PLS-cu patients showed decreased FA in the mid-body of corpus callosum. In PLS, executive and language test scores correlated with WM damage.<h4>Conclusions</h4>This is the first study evaluating the relationship between cognitive performance and WM tract damage in PLS patients. PLS can be associated with a multi-domain cognitive impairment. WM damage to interhemispheric, limbic and major associative WM tracts seem to be the structural correlate of cognitive abnormalities in these patients.
format	article
author	Elisa Canu Federica Agosta Sebastiano Galantucci Adriano Chiò Nilo Riva Vincenzo Silani Andrea Falini Giancarlo Comi Massimo Filippi
author_facet	Elisa Canu Federica Agosta Sebastiano Galantucci Adriano Chiò Nilo Riva Vincenzo Silani Andrea Falini Giancarlo Comi Massimo Filippi
author_sort	Elisa Canu
title	Extramotor damage is associated with cognition in primary lateral sclerosis patients.
title_short	Extramotor damage is associated with cognition in primary lateral sclerosis patients.
title_full	Extramotor damage is associated with cognition in primary lateral sclerosis patients.
title_fullStr	Extramotor damage is associated with cognition in primary lateral sclerosis patients.
title_full_unstemmed	Extramotor damage is associated with cognition in primary lateral sclerosis patients.
title_sort	extramotor damage is associated with cognition in primary lateral sclerosis patients.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/b175141d8cbf49a1b461ce7fae973621
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Extramotor damage is associated with cognition in primary lateral sclerosis patients.

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