The structural basis of translational control by eIF2 phosphorylation

The structural basis of translational control by eIF2 phosphorylation

During the integrated stress response, translation is modulated through the phosphorylation of translation initiation factor eIF2 and the formation of a complex with eIF2B. Here the authors present structures of the eIF2:eIF2B complex with and without phosphorylation, shedding light on how eIF2 phos...

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Autores principales: Tomas Adomavicius, Margherita Guaita, Yu Zhou, Martin D. Jennings, Zakia Latif, Alan M. Roseman, Graham D. Pavitt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/b178b1da56a2498cb1e4d2d9ec16bc26
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spelling oai:doaj.org-article:b178b1da56a2498cb1e4d2d9ec16bc262021-12-02T16:58:07ZThe structural basis of translational control by eIF2 phosphorylation10.1038/s41467-019-10167-32041-1723https://doaj.org/article/b178b1da56a2498cb1e4d2d9ec16bc262019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10167-3https://doaj.org/toc/2041-1723During the integrated stress response, translation is modulated through the phosphorylation of translation initiation factor eIF2 and the formation of a complex with eIF2B. Here the authors present structures of the eIF2:eIF2B complex with and without phosphorylation, shedding light on how eIF2 phosphorylation regulates translation.Tomas AdomaviciusMargherita GuaitaYu ZhouMartin D. JenningsZakia LatifAlan M. RosemanGraham D. PavittNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tomas Adomavicius
Margherita Guaita
Yu Zhou
Martin D. Jennings
Zakia Latif
Alan M. Roseman
Graham D. Pavitt
The structural basis of translational control by eIF2 phosphorylation
description During the integrated stress response, translation is modulated through the phosphorylation of translation initiation factor eIF2 and the formation of a complex with eIF2B. Here the authors present structures of the eIF2:eIF2B complex with and without phosphorylation, shedding light on how eIF2 phosphorylation regulates translation.
format article
author Tomas Adomavicius
Margherita Guaita
Yu Zhou
Martin D. Jennings
Zakia Latif
Alan M. Roseman
Graham D. Pavitt
author_facet Tomas Adomavicius
Margherita Guaita
Yu Zhou
Martin D. Jennings
Zakia Latif
Alan M. Roseman
Graham D. Pavitt
author_sort Tomas Adomavicius
title The structural basis of translational control by eIF2 phosphorylation
title_short The structural basis of translational control by eIF2 phosphorylation
title_full The structural basis of translational control by eIF2 phosphorylation
title_fullStr The structural basis of translational control by eIF2 phosphorylation
title_full_unstemmed The structural basis of translational control by eIF2 phosphorylation
title_sort structural basis of translational control by eif2 phosphorylation
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/b178b1da56a2498cb1e4d2d9ec16bc26
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