Mortality and suicide risk in treatment-resistant depression: an observational study of the long-term impact of intervention.

Major depressive disorder is a common global disease that causes a significant societal burden. Most interventional studies of depression provide a limited assessment of the interventions on mortality and suicide risks. This study utilizes data from an observational registry of patients with major d...

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Autores principales:	Bryan Olin, Amara K Jayewardene, Mark Bunker, Francisco Moreno
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b17923b341a5416fb911e221490c6899
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spelling	oai:doaj.org-article:b17923b341a5416fb911e221490c68992021-11-18T08:11:00ZMortality and suicide risk in treatment-resistant depression: an observational study of the long-term impact of intervention.1932-620310.1371/journal.pone.0048002https://doaj.org/article/b17923b341a5416fb911e221490c68992012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23133537/?tool=EBIhttps://doaj.org/toc/1932-6203Major depressive disorder is a common global disease that causes a significant societal burden. Most interventional studies of depression provide a limited assessment of the interventions on mortality and suicide risks. This study utilizes data from an observational registry of patients with major depressive disorder to determine the impact of intervention (vagus nerve stimulation or standard pharmacological/non-pharmacological therapy) and a latent factor, patient trajectory toward response, on mortality, suicide and suicidal ideation. A total of 636 patients were available for an intent-to-treat analysis of all-cause mortality, suicide and suicidal ideation. Patients treated with vagus nerve stimulation in addition to standard therapies experienced lower, but not statistically significant, all-cause mortality (vagus nerve stimulation 4.93 per 1,000 person-years vs. 10.02 per 1,000 patient years for treatment as usual) and suicide rates (vagus nerve stimulation 0.88 per 1,000 person-years vs. 1.61 per 1,000 patient years for treatment as usual). Treatment with vagus nerve stimulation produced a statistically lower relative risk of suicidal ideation 0.80, 95% confidence interval (0.68,0.95). Further, patients that responded to either treatment saw a 51% reduction in relative risk of suicidal behavior; relative risk and 95% confidence interval of 0.49 (0.41,0.58). In summary, we find that treatment with adjunctive vagus nerve stimulation can potentially lower the risk of all-cause mortality, suicide and suicide attempts.Bryan OlinAmara K JayewardeneMark BunkerFrancisco MorenoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e48002 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bryan Olin Amara K Jayewardene Mark Bunker Francisco Moreno Mortality and suicide risk in treatment-resistant depression: an observational study of the long-term impact of intervention.
description	Major depressive disorder is a common global disease that causes a significant societal burden. Most interventional studies of depression provide a limited assessment of the interventions on mortality and suicide risks. This study utilizes data from an observational registry of patients with major depressive disorder to determine the impact of intervention (vagus nerve stimulation or standard pharmacological/non-pharmacological therapy) and a latent factor, patient trajectory toward response, on mortality, suicide and suicidal ideation. A total of 636 patients were available for an intent-to-treat analysis of all-cause mortality, suicide and suicidal ideation. Patients treated with vagus nerve stimulation in addition to standard therapies experienced lower, but not statistically significant, all-cause mortality (vagus nerve stimulation 4.93 per 1,000 person-years vs. 10.02 per 1,000 patient years for treatment as usual) and suicide rates (vagus nerve stimulation 0.88 per 1,000 person-years vs. 1.61 per 1,000 patient years for treatment as usual). Treatment with vagus nerve stimulation produced a statistically lower relative risk of suicidal ideation 0.80, 95% confidence interval (0.68,0.95). Further, patients that responded to either treatment saw a 51% reduction in relative risk of suicidal behavior; relative risk and 95% confidence interval of 0.49 (0.41,0.58). In summary, we find that treatment with adjunctive vagus nerve stimulation can potentially lower the risk of all-cause mortality, suicide and suicide attempts.
format	article
author	Bryan Olin Amara K Jayewardene Mark Bunker Francisco Moreno
author_facet	Bryan Olin Amara K Jayewardene Mark Bunker Francisco Moreno
author_sort	Bryan Olin
title	Mortality and suicide risk in treatment-resistant depression: an observational study of the long-term impact of intervention.
title_short	Mortality and suicide risk in treatment-resistant depression: an observational study of the long-term impact of intervention.
title_full	Mortality and suicide risk in treatment-resistant depression: an observational study of the long-term impact of intervention.
title_fullStr	Mortality and suicide risk in treatment-resistant depression: an observational study of the long-term impact of intervention.
title_full_unstemmed	Mortality and suicide risk in treatment-resistant depression: an observational study of the long-term impact of intervention.
title_sort	mortality and suicide risk in treatment-resistant depression: an observational study of the long-term impact of intervention.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/b17923b341a5416fb911e221490c6899
work_keys_str_mv	AT bryanolin mortalityandsuicideriskintreatmentresistantdepressionanobservationalstudyofthelongtermimpactofintervention AT amarakjayewardene mortalityandsuicideriskintreatmentresistantdepressionanobservationalstudyofthelongtermimpactofintervention AT markbunker mortalityandsuicideriskintreatmentresistantdepressionanobservationalstudyofthelongtermimpactofintervention AT franciscomoreno mortalityandsuicideriskintreatmentresistantdepressionanobservationalstudyofthelongtermimpactofintervention
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Mortality and suicide risk in treatment-resistant depression: an observational study of the long-term impact of intervention.

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