Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos

The mechanisms of sensing of blood flow and responses to it in vascular remodelling are poorly understood. Here, the authors show that in zebrafish blood flow controls both the fate determination of individual blood vessels and the arterial versus venous identity of endothelial cells lining them.

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Autores principales:	Bart Weijts, Edgar Gutierrez, Semion K. Saikin, Ararat J. Ablooglu, David Traver, Alex Groisman, Eugene Tkachenko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b1794bd622bc45d3a2fefd0e655fefd7
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spelling	oai:doaj.org-article:b1794bd622bc45d3a2fefd0e655fefd72021-12-02T14:39:45ZBlood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos10.1038/s41467-018-07732-72041-1723https://doaj.org/article/b1794bd622bc45d3a2fefd0e655fefd72018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07732-7https://doaj.org/toc/2041-1723The mechanisms of sensing of blood flow and responses to it in vascular remodelling are poorly understood. Here, the authors show that in zebrafish blood flow controls both the fate determination of individual blood vessels and the arterial versus venous identity of endothelial cells lining them.Bart WeijtsEdgar GutierrezSemion K. SaikinArarat J. AbloogluDavid TraverAlex GroismanEugene TkachenkoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bart Weijts Edgar Gutierrez Semion K. Saikin Ararat J. Ablooglu David Traver Alex Groisman Eugene Tkachenko Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos
description	The mechanisms of sensing of blood flow and responses to it in vascular remodelling are poorly understood. Here, the authors show that in zebrafish blood flow controls both the fate determination of individual blood vessels and the arterial versus venous identity of endothelial cells lining them.
format	article
author	Bart Weijts Edgar Gutierrez Semion K. Saikin Ararat J. Ablooglu David Traver Alex Groisman Eugene Tkachenko
author_facet	Bart Weijts Edgar Gutierrez Semion K. Saikin Ararat J. Ablooglu David Traver Alex Groisman Eugene Tkachenko
author_sort	Bart Weijts
title	Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos
title_short	Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos
title_full	Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos
title_fullStr	Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos
title_full_unstemmed	Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos
title_sort	blood flow-induced notch activation and endothelial migration enable vascular remodeling in zebrafish embryos
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b1794bd622bc45d3a2fefd0e655fefd7
work_keys_str_mv	AT bartweijts bloodflowinducednotchactivationandendothelialmigrationenablevascularremodelinginzebrafishembryos AT edgargutierrez bloodflowinducednotchactivationandendothelialmigrationenablevascularremodelinginzebrafishembryos AT semionksaikin bloodflowinducednotchactivationandendothelialmigrationenablevascularremodelinginzebrafishembryos AT araratjablooglu bloodflowinducednotchactivationandendothelialmigrationenablevascularremodelinginzebrafishembryos AT davidtraver bloodflowinducednotchactivationandendothelialmigrationenablevascularremodelinginzebrafishembryos AT alexgroisman bloodflowinducednotchactivationandendothelialmigrationenablevascularremodelinginzebrafishembryos AT eugenetkachenko bloodflowinducednotchactivationandendothelialmigrationenablevascularremodelinginzebrafishembryos
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Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos

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