Assessing the causal association of glycine with risk of cardio-metabolic diseases

Epidemiological studies have associated circulating levels of the amino acid glycine with cardiometabolic outcomes. Here, in a genome-wide meta-analysis of 80,003 individuals, Wittemans et al. identify 22 novel genetic loci for glycine and find a causal relationship with coronary heart disease using...

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Autores principales:	Laura B. L. Wittemans, Luca A. Lotta, Clare Oliver-Williams, Isobel D. Stewart, Praveen Surendran, Savita Karthikeyan, Felix R. Day, Albert Koulman, Fumiaki Imamura, Lingyao Zeng, Jeanette Erdmann, Heribert Schunkert, Kay-Tee Khaw, Julian L. Griffin, Nita G. Forouhi, Robert A. Scott, Angela M. Wood, Stephen Burgess, Joanna M. M. Howson, John Danesh, Nicholas J. Wareham, Adam S. Butterworth, Claudia Langenberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b179b3632faa45f4b864e7498db649ab
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spelling	oai:doaj.org-article:b179b3632faa45f4b864e7498db649ab2021-12-02T16:57:45ZAssessing the causal association of glycine with risk of cardio-metabolic diseases10.1038/s41467-019-08936-12041-1723https://doaj.org/article/b179b3632faa45f4b864e7498db649ab2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08936-1https://doaj.org/toc/2041-1723Epidemiological studies have associated circulating levels of the amino acid glycine with cardiometabolic outcomes. Here, in a genome-wide meta-analysis of 80,003 individuals, Wittemans et al. identify 22 novel genetic loci for glycine and find a causal relationship with coronary heart disease using MR.Laura B. L. WittemansLuca A. LottaClare Oliver-WilliamsIsobel D. StewartPraveen SurendranSavita KarthikeyanFelix R. DayAlbert KoulmanFumiaki ImamuraLingyao ZengJeanette ErdmannHeribert SchunkertKay-Tee KhawJulian L. GriffinNita G. ForouhiRobert A. ScottAngela M. WoodStephen BurgessJoanna M. M. HowsonJohn DaneshNicholas J. WarehamAdam S. ButterworthClaudia LangenbergNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura B. L. Wittemans Luca A. Lotta Clare Oliver-Williams Isobel D. Stewart Praveen Surendran Savita Karthikeyan Felix R. Day Albert Koulman Fumiaki Imamura Lingyao Zeng Jeanette Erdmann Heribert Schunkert Kay-Tee Khaw Julian L. Griffin Nita G. Forouhi Robert A. Scott Angela M. Wood Stephen Burgess Joanna M. M. Howson John Danesh Nicholas J. Wareham Adam S. Butterworth Claudia Langenberg Assessing the causal association of glycine with risk of cardio-metabolic diseases
description	Epidemiological studies have associated circulating levels of the amino acid glycine with cardiometabolic outcomes. Here, in a genome-wide meta-analysis of 80,003 individuals, Wittemans et al. identify 22 novel genetic loci for glycine and find a causal relationship with coronary heart disease using MR.
format	article
author	Laura B. L. Wittemans Luca A. Lotta Clare Oliver-Williams Isobel D. Stewart Praveen Surendran Savita Karthikeyan Felix R. Day Albert Koulman Fumiaki Imamura Lingyao Zeng Jeanette Erdmann Heribert Schunkert Kay-Tee Khaw Julian L. Griffin Nita G. Forouhi Robert A. Scott Angela M. Wood Stephen Burgess Joanna M. M. Howson John Danesh Nicholas J. Wareham Adam S. Butterworth Claudia Langenberg
author_facet	Laura B. L. Wittemans Luca A. Lotta Clare Oliver-Williams Isobel D. Stewart Praveen Surendran Savita Karthikeyan Felix R. Day Albert Koulman Fumiaki Imamura Lingyao Zeng Jeanette Erdmann Heribert Schunkert Kay-Tee Khaw Julian L. Griffin Nita G. Forouhi Robert A. Scott Angela M. Wood Stephen Burgess Joanna M. M. Howson John Danesh Nicholas J. Wareham Adam S. Butterworth Claudia Langenberg
author_sort	Laura B. L. Wittemans
title	Assessing the causal association of glycine with risk of cardio-metabolic diseases
title_short	Assessing the causal association of glycine with risk of cardio-metabolic diseases
title_full	Assessing the causal association of glycine with risk of cardio-metabolic diseases
title_fullStr	Assessing the causal association of glycine with risk of cardio-metabolic diseases
title_full_unstemmed	Assessing the causal association of glycine with risk of cardio-metabolic diseases
title_sort	assessing the causal association of glycine with risk of cardio-metabolic diseases
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b179b3632faa45f4b864e7498db649ab
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Assessing the causal association of glycine with risk of cardio-metabolic diseases

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