Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis

Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis

Karmakar et al produced a dermotropic, live attenuated centrin gene-deleted Leishmania major (LmCen −/− ) vaccine against Visceral Leishmaniasis (VL). They demonstrated in hamsters that a single intradermal injection confers robust and durable protection against lethal VL that is transmitted natural...

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Autores principales: Subir Karmakar, Nevien Ismail, Fabiano Oliveira, James Oristian, Wen Wei Zhang, Swarnendu Kaviraj, Kamaleshwar P. Singh, Abhishek Mondal, Sushmita Das, Krishna Pandey, Parna Bhattacharya, Greta Volpedo, Sreenivas Gannavaram, Monika Satoskar, Sanika Satoskar, Rajiv M. Sastry, Timur Oljuskin, Telly Sepahpour, Claudio Meneses, Shinjiro Hamano, Pradeep Das, Greg Matlashewski, Sanjay Singh, Shaden Kamhawi, Ranadhir Dey, Jesus G. Valenzuela, Abhay Satoskar, Hira L. Nakhasi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/b17a11a8c0a341a0abe1473e6b12a4ae
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spelling oai:doaj.org-article:b17a11a8c0a341a0abe1473e6b12a4ae2021-12-02T16:31:01ZPreclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis10.1038/s42003-021-02446-x2399-3642https://doaj.org/article/b17a11a8c0a341a0abe1473e6b12a4ae2021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02446-xhttps://doaj.org/toc/2399-3642Karmakar et al produced a dermotropic, live attenuated centrin gene-deleted Leishmania major (LmCen −/− ) vaccine against Visceral Leishmaniasis (VL). They demonstrated in hamsters that a single intradermal injection confers robust and durable protection against lethal VL that is transmitted naturally via bites of L. donovani-infected sand flies.Subir KarmakarNevien IsmailFabiano OliveiraJames OristianWen Wei ZhangSwarnendu KavirajKamaleshwar P. SinghAbhishek MondalSushmita DasKrishna PandeyParna BhattacharyaGreta VolpedoSreenivas GannavaramMonika SatoskarSanika SatoskarRajiv M. SastryTimur OljuskinTelly SepahpourClaudio MenesesShinjiro HamanoPradeep DasGreg MatlashewskiSanjay SinghShaden KamhawiRanadhir DeyJesus G. ValenzuelaAbhay SatoskarHira L. NakhasiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Subir Karmakar
Nevien Ismail
Fabiano Oliveira
James Oristian
Wen Wei Zhang
Swarnendu Kaviraj
Kamaleshwar P. Singh
Abhishek Mondal
Sushmita Das
Krishna Pandey
Parna Bhattacharya
Greta Volpedo
Sreenivas Gannavaram
Monika Satoskar
Sanika Satoskar
Rajiv M. Sastry
Timur Oljuskin
Telly Sepahpour
Claudio Meneses
Shinjiro Hamano
Pradeep Das
Greg Matlashewski
Sanjay Singh
Shaden Kamhawi
Ranadhir Dey
Jesus G. Valenzuela
Abhay Satoskar
Hira L. Nakhasi
Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis
description Karmakar et al produced a dermotropic, live attenuated centrin gene-deleted Leishmania major (LmCen −/− ) vaccine against Visceral Leishmaniasis (VL). They demonstrated in hamsters that a single intradermal injection confers robust and durable protection against lethal VL that is transmitted naturally via bites of L. donovani-infected sand flies.
format article
author Subir Karmakar
Nevien Ismail
Fabiano Oliveira
James Oristian
Wen Wei Zhang
Swarnendu Kaviraj
Kamaleshwar P. Singh
Abhishek Mondal
Sushmita Das
Krishna Pandey
Parna Bhattacharya
Greta Volpedo
Sreenivas Gannavaram
Monika Satoskar
Sanika Satoskar
Rajiv M. Sastry
Timur Oljuskin
Telly Sepahpour
Claudio Meneses
Shinjiro Hamano
Pradeep Das
Greg Matlashewski
Sanjay Singh
Shaden Kamhawi
Ranadhir Dey
Jesus G. Valenzuela
Abhay Satoskar
Hira L. Nakhasi
author_facet Subir Karmakar
Nevien Ismail
Fabiano Oliveira
James Oristian
Wen Wei Zhang
Swarnendu Kaviraj
Kamaleshwar P. Singh
Abhishek Mondal
Sushmita Das
Krishna Pandey
Parna Bhattacharya
Greta Volpedo
Sreenivas Gannavaram
Monika Satoskar
Sanika Satoskar
Rajiv M. Sastry
Timur Oljuskin
Telly Sepahpour
Claudio Meneses
Shinjiro Hamano
Pradeep Das
Greg Matlashewski
Sanjay Singh
Shaden Kamhawi
Ranadhir Dey
Jesus G. Valenzuela
Abhay Satoskar
Hira L. Nakhasi
author_sort Subir Karmakar
title Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis
title_short Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis
title_full Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis
title_fullStr Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis
title_full_unstemmed Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis
title_sort preclinical validation of a live attenuated dermotropic leishmania vaccine against vector transmitted fatal visceral leishmaniasis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/b17a11a8c0a341a0abe1473e6b12a4ae
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