Biology and Treatment of High-Risk CLL: Significance of Complex Karyotype

Several reports highlight the clinical significance of cytogenetic complexity, namely, complex karyotype (CK) identified though the performance of chromosome banding analysis (CBA) in chronic lymphocytic leukemia. Indeed, apart from a number of studies underscoring the prognostic and predictive valu...

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Autores principales:	Thomas Chatzikonstantinou, Christos Demosthenous, Panagiotis Baliakas
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	CLL (chronic lymphocytic leukemia) prognosis prediction high-risk complex karyotype (CK) cytogenetic complexity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/b17c11394e714496b2483db75544f1ef
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spelling	oai:doaj.org-article:b17c11394e714496b2483db75544f1ef2021-12-01T13:30:57ZBiology and Treatment of High-Risk CLL: Significance of Complex Karyotype2234-943X10.3389/fonc.2021.788761https://doaj.org/article/b17c11394e714496b2483db75544f1ef2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.788761/fullhttps://doaj.org/toc/2234-943XSeveral reports highlight the clinical significance of cytogenetic complexity, namely, complex karyotype (CK) identified though the performance of chromosome banding analysis (CBA) in chronic lymphocytic leukemia. Indeed, apart from a number of studies underscoring the prognostic and predictive value of CK in the chemo(immune)therapy era, mounting evidence suggests that CK could serve as an independent prognosticator and predictor even in patients treated with novel agents. In the present review, we provide an overview of the current knowledge regarding the clinical impact of CK in CLL, touching upon open issues related to the incorporation of CK in the clinical setting.Thomas ChatzikonstantinouChristos DemosthenousPanagiotis BaliakasPanagiotis BaliakasFrontiers Media S.A.articleCLL (chronic lymphocytic leukemia)prognosispredictionhigh-riskcomplex karyotype (CK)cytogenetic complexityNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CLL (chronic lymphocytic leukemia) prognosis prediction high-risk complex karyotype (CK) cytogenetic complexity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	CLL (chronic lymphocytic leukemia) prognosis prediction high-risk complex karyotype (CK) cytogenetic complexity Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Thomas Chatzikonstantinou Christos Demosthenous Panagiotis Baliakas Panagiotis Baliakas Biology and Treatment of High-Risk CLL: Significance of Complex Karyotype
description	Several reports highlight the clinical significance of cytogenetic complexity, namely, complex karyotype (CK) identified though the performance of chromosome banding analysis (CBA) in chronic lymphocytic leukemia. Indeed, apart from a number of studies underscoring the prognostic and predictive value of CK in the chemo(immune)therapy era, mounting evidence suggests that CK could serve as an independent prognosticator and predictor even in patients treated with novel agents. In the present review, we provide an overview of the current knowledge regarding the clinical impact of CK in CLL, touching upon open issues related to the incorporation of CK in the clinical setting.
format	article
author	Thomas Chatzikonstantinou Christos Demosthenous Panagiotis Baliakas Panagiotis Baliakas
author_facet	Thomas Chatzikonstantinou Christos Demosthenous Panagiotis Baliakas Panagiotis Baliakas
author_sort	Thomas Chatzikonstantinou
title	Biology and Treatment of High-Risk CLL: Significance of Complex Karyotype
title_short	Biology and Treatment of High-Risk CLL: Significance of Complex Karyotype
title_full	Biology and Treatment of High-Risk CLL: Significance of Complex Karyotype
title_fullStr	Biology and Treatment of High-Risk CLL: Significance of Complex Karyotype
title_full_unstemmed	Biology and Treatment of High-Risk CLL: Significance of Complex Karyotype
title_sort	biology and treatment of high-risk cll: significance of complex karyotype
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b17c11394e714496b2483db75544f1ef
work_keys_str_mv	AT thomaschatzikonstantinou biologyandtreatmentofhighriskcllsignificanceofcomplexkaryotype AT christosdemosthenous biologyandtreatmentofhighriskcllsignificanceofcomplexkaryotype AT panagiotisbaliakas biologyandtreatmentofhighriskcllsignificanceofcomplexkaryotype AT panagiotisbaliakas biologyandtreatmentofhighriskcllsignificanceofcomplexkaryotype
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Biology and Treatment of High-Risk CLL: Significance of Complex Karyotype

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