Plasticity within excitatory and inhibitory pathways of the vestibulo-spinal circuitry guides changes in motor performance

Abstract Investigations of behaviors with well-characterized circuitry are required to understand how the brain learns new motor skills and ensures existing behaviors remain appropriately calibrated over time. Accordingly, here we recorded from neurons within different sites of the vestibulo-spinal...

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Autores principales:	Diana E. Mitchell, Charles C. Della Santina, Kathleen E. Cullen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b17c1f4234fd4f499e1a42d22d542c4f
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spelling	oai:doaj.org-article:b17c1f4234fd4f499e1a42d22d542c4f2021-12-02T12:32:06ZPlasticity within excitatory and inhibitory pathways of the vestibulo-spinal circuitry guides changes in motor performance10.1038/s41598-017-00956-52045-2322https://doaj.org/article/b17c1f4234fd4f499e1a42d22d542c4f2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00956-5https://doaj.org/toc/2045-2322Abstract Investigations of behaviors with well-characterized circuitry are required to understand how the brain learns new motor skills and ensures existing behaviors remain appropriately calibrated over time. Accordingly, here we recorded from neurons within different sites of the vestibulo-spinal circuitry of behaving macaque monkeys during temporally precise activation of vestibular afferents. Behaviorally relevant patterns of vestibular nerve activation generated a rapid and substantial decrease in the monosynaptic responses recorded at the first central stage of processing from neurons receiving direct input from vestibular afferents within minutes, as well as a decrease in the compensatory reflex response that lasted up to 8 hours. In contrast, afferent responses to this same stimulation remained constant, indicating that plasticity was not induced at the level of the periphery but rather at the afferent-central neuron synapse. Strikingly, the responses of neurons within indirect brainstem pathways also remained constant, even though the efficacy of their central input was significantly reduced. Taken together, our results show that rapid plasticity at the first central stage of vestibulo-spinal pathways can guide changes in motor performance, and that complementary plasticity on the same millisecond time scale within inhibitory vestibular nuclei networks contributes to ensuring a relatively robust behavioral output.Diana E. MitchellCharles C. Della SantinaKathleen E. CullenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Diana E. Mitchell Charles C. Della Santina Kathleen E. Cullen Plasticity within excitatory and inhibitory pathways of the vestibulo-spinal circuitry guides changes in motor performance
description	Abstract Investigations of behaviors with well-characterized circuitry are required to understand how the brain learns new motor skills and ensures existing behaviors remain appropriately calibrated over time. Accordingly, here we recorded from neurons within different sites of the vestibulo-spinal circuitry of behaving macaque monkeys during temporally precise activation of vestibular afferents. Behaviorally relevant patterns of vestibular nerve activation generated a rapid and substantial decrease in the monosynaptic responses recorded at the first central stage of processing from neurons receiving direct input from vestibular afferents within minutes, as well as a decrease in the compensatory reflex response that lasted up to 8 hours. In contrast, afferent responses to this same stimulation remained constant, indicating that plasticity was not induced at the level of the periphery but rather at the afferent-central neuron synapse. Strikingly, the responses of neurons within indirect brainstem pathways also remained constant, even though the efficacy of their central input was significantly reduced. Taken together, our results show that rapid plasticity at the first central stage of vestibulo-spinal pathways can guide changes in motor performance, and that complementary plasticity on the same millisecond time scale within inhibitory vestibular nuclei networks contributes to ensuring a relatively robust behavioral output.
format	article
author	Diana E. Mitchell Charles C. Della Santina Kathleen E. Cullen
author_facet	Diana E. Mitchell Charles C. Della Santina Kathleen E. Cullen
author_sort	Diana E. Mitchell
title	Plasticity within excitatory and inhibitory pathways of the vestibulo-spinal circuitry guides changes in motor performance
title_short	Plasticity within excitatory and inhibitory pathways of the vestibulo-spinal circuitry guides changes in motor performance
title_full	Plasticity within excitatory and inhibitory pathways of the vestibulo-spinal circuitry guides changes in motor performance
title_fullStr	Plasticity within excitatory and inhibitory pathways of the vestibulo-spinal circuitry guides changes in motor performance
title_full_unstemmed	Plasticity within excitatory and inhibitory pathways of the vestibulo-spinal circuitry guides changes in motor performance
title_sort	plasticity within excitatory and inhibitory pathways of the vestibulo-spinal circuitry guides changes in motor performance
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b17c1f4234fd4f499e1a42d22d542c4f
work_keys_str_mv	AT dianaemitchell plasticitywithinexcitatoryandinhibitorypathwaysofthevestibulospinalcircuitryguideschangesinmotorperformance AT charlescdellasantina plasticitywithinexcitatoryandinhibitorypathwaysofthevestibulospinalcircuitryguideschangesinmotorperformance AT kathleenecullen plasticitywithinexcitatoryandinhibitorypathwaysofthevestibulospinalcircuitryguideschangesinmotorperformance
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Plasticity within excitatory and inhibitory pathways of the vestibulo-spinal circuitry guides changes in motor performance

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