Fabry disease: a survey of visual and ocular symptoms

Pinakin Gunvant Davey Western University of Health Sciences, College of Optometry, Pomona, CA, USA Purpose: To evaluate a visual symptoms survey on patients with a known diagnosis of Fabry disease, and to compare the scores to those from a group of healthy subjects.Materials and methods: An ocula...

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Autor principal:	Davey PG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/b17e38e9abb3408f872125f052eb75f0
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spelling	oai:doaj.org-article:b17e38e9abb3408f872125f052eb75f02021-12-02T02:49:31ZFabry disease: a survey of visual and ocular symptoms1177-5483https://doaj.org/article/b17e38e9abb3408f872125f052eb75f02014-08-01T00:00:00Zhttp://www.dovepress.com/fabry-disease-a-survey-of-visual-and-ocular-symptoms-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Pinakin Gunvant Davey Western University of Health Sciences, College of Optometry, Pomona, CA, USA Purpose: To evaluate a visual symptoms survey on patients with a known diagnosis of Fabry disease, and to compare the scores to those from a group of healthy subjects.Materials and methods: An ocular symptom survey instrument was used to evaluate the symptoms of general ocular problems like itching, tearing, dryness, burning sensation, sensation of foreign body, difficulty in scotopic and photopic vision, and asthenopic symptoms. The survey instrument was administered to 95 participants (75 patients with Fabry disease and 20 healthy controls; median age: 32.5 years [standard deviation: 19.1 years] and 42.6 years [standard deviation: 14.7 years], respectively). A Mann–Whitney test was performed to evaluate the difference between the Fabry group and the healthy controls for each symptom survey severity score. A P-value <0.05 was considered significant. Results: Of the survey instrument items, it was found that compared to the control group, the mean severity score of the Fabry disease group was significant for “dryness” of the eyes (P=0.02), “blurry/dim vision” (P=0.02), “hard to see in dark places” (P=0.01), and “halos around light” (P=0.01). The Fabry group also had a mean severity score for “soreness/tiredness” that was significantly higher than that of the control group (P=0.009).Conclusion: The patients with Fabry disease may be suffering from ocular and visual symptoms related to manifestations of the disease. Further quantitative testing is needed to investigate the ocular and visual symptoms. Keywords: Fabry disease, lysosomal storage disease, visual symptomsDavey PGDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 1555-1560 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Davey PG Fabry disease: a survey of visual and ocular symptoms
description	Pinakin Gunvant Davey Western University of Health Sciences, College of Optometry, Pomona, CA, USA Purpose: To evaluate a visual symptoms survey on patients with a known diagnosis of Fabry disease, and to compare the scores to those from a group of healthy subjects.Materials and methods: An ocular symptom survey instrument was used to evaluate the symptoms of general ocular problems like itching, tearing, dryness, burning sensation, sensation of foreign body, difficulty in scotopic and photopic vision, and asthenopic symptoms. The survey instrument was administered to 95 participants (75 patients with Fabry disease and 20 healthy controls; median age: 32.5 years [standard deviation: 19.1 years] and 42.6 years [standard deviation: 14.7 years], respectively). A Mann–Whitney test was performed to evaluate the difference between the Fabry group and the healthy controls for each symptom survey severity score. A P-value <0.05 was considered significant. Results: Of the survey instrument items, it was found that compared to the control group, the mean severity score of the Fabry disease group was significant for “dryness” of the eyes (P=0.02), “blurry/dim vision” (P=0.02), “hard to see in dark places” (P=0.01), and “halos around light” (P=0.01). The Fabry group also had a mean severity score for “soreness/tiredness” that was significantly higher than that of the control group (P=0.009).Conclusion: The patients with Fabry disease may be suffering from ocular and visual symptoms related to manifestations of the disease. Further quantitative testing is needed to investigate the ocular and visual symptoms. Keywords: Fabry disease, lysosomal storage disease, visual symptoms
format	article
author	Davey PG
author_facet	Davey PG
author_sort	Davey PG
title	Fabry disease: a survey of visual and ocular symptoms
title_short	Fabry disease: a survey of visual and ocular symptoms
title_full	Fabry disease: a survey of visual and ocular symptoms
title_fullStr	Fabry disease: a survey of visual and ocular symptoms
title_full_unstemmed	Fabry disease: a survey of visual and ocular symptoms
title_sort	fabry disease: a survey of visual and ocular symptoms
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/b17e38e9abb3408f872125f052eb75f0
work_keys_str_mv	AT daveypg fabrydiseaseasurveyofvisualandocularsymptoms
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Fabry disease: a survey of visual and ocular symptoms

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