Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk

QTL mapping in multicellular animals usually requires generation, maintenance, and phenotyping large panels of recombinant individuals. Here, the authors develop ceX-QTL mapping, a method for fast genetic mapping via bulk selection on millions of unique recombinant C. elegans individuals.

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Auteurs principaux: Alejandro Burga, Eyal Ben-David, Tzitziki Lemus Vergara, James Boocock, Leonid Kruglyak
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/b17ed630d0ca4c1388dd18e8c45b47a7
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Résumé:QTL mapping in multicellular animals usually requires generation, maintenance, and phenotyping large panels of recombinant individuals. Here, the authors develop ceX-QTL mapping, a method for fast genetic mapping via bulk selection on millions of unique recombinant C. elegans individuals.