Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk

QTL mapping in multicellular animals usually requires generation, maintenance, and phenotyping large panels of recombinant individuals. Here, the authors develop ceX-QTL mapping, a method for fast genetic mapping via bulk selection on millions of unique recombinant C. elegans individuals.

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Bibliographic Details
Main Authors: Alejandro Burga, Eyal Ben-David, Tzitziki Lemus Vergara, James Boocock, Leonid Kruglyak
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Q
Online Access:https://doaj.org/article/b17ed630d0ca4c1388dd18e8c45b47a7
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Description
Summary:QTL mapping in multicellular animals usually requires generation, maintenance, and phenotyping large panels of recombinant individuals. Here, the authors develop ceX-QTL mapping, a method for fast genetic mapping via bulk selection on millions of unique recombinant C. elegans individuals.