Identifying side effects of commonly used drugs in the treatment of Covid 19

Abstract To increase the success in Covid 19 treatment, many drug suggestions are presented, and some clinical studies are shared in the literature. There have been some attempts to use some of these drugs in combination. However, using more than one drug together may cause serious side effects on p...

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Autores principales:	İrfan Aygün, Mehmet Kaya, Reda Alhajj
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b180765350b04456acc6e3f68515be48
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spelling	oai:doaj.org-article:b180765350b04456acc6e3f68515be482021-12-02T11:43:36ZIdentifying side effects of commonly used drugs in the treatment of Covid 1910.1038/s41598-020-78697-12045-2322https://doaj.org/article/b180765350b04456acc6e3f68515be482020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78697-1https://doaj.org/toc/2045-2322Abstract To increase the success in Covid 19 treatment, many drug suggestions are presented, and some clinical studies are shared in the literature. There have been some attempts to use some of these drugs in combination. However, using more than one drug together may cause serious side effects on patients. Therefore, detecting drug-drug interactions of the drugs used will be of great importance in the treatment of Covid 19. In this study, the interactions of 8 drugs used for Covid 19 treatment with 645 different drugs and possible side effects estimates have been produced using Graph Convolutional Networks. As a result of the experiments, it has been found that the hematopoietic system and the cardiovascular system are exposed to more side effects than other organs. Among the focused drugs, Heparin and Atazanavir appear to cause more adverse reactions than other drugs. In addition, as it is known that some of these 8 drugs are used together in Covid-19 treatment, the side effects caused by using these drugs together are shared. With the experimental results obtained, it is aimed to facilitate the selection of the drugs and increase the success of Covid 19 treatment according to the targeted patient.İrfan AygünMehmet KayaReda AlhajjNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q İrfan Aygün Mehmet Kaya Reda Alhajj Identifying side effects of commonly used drugs in the treatment of Covid 19
description	Abstract To increase the success in Covid 19 treatment, many drug suggestions are presented, and some clinical studies are shared in the literature. There have been some attempts to use some of these drugs in combination. However, using more than one drug together may cause serious side effects on patients. Therefore, detecting drug-drug interactions of the drugs used will be of great importance in the treatment of Covid 19. In this study, the interactions of 8 drugs used for Covid 19 treatment with 645 different drugs and possible side effects estimates have been produced using Graph Convolutional Networks. As a result of the experiments, it has been found that the hematopoietic system and the cardiovascular system are exposed to more side effects than other organs. Among the focused drugs, Heparin and Atazanavir appear to cause more adverse reactions than other drugs. In addition, as it is known that some of these 8 drugs are used together in Covid-19 treatment, the side effects caused by using these drugs together are shared. With the experimental results obtained, it is aimed to facilitate the selection of the drugs and increase the success of Covid 19 treatment according to the targeted patient.
format	article
author	İrfan Aygün Mehmet Kaya Reda Alhajj
author_facet	İrfan Aygün Mehmet Kaya Reda Alhajj
author_sort	İrfan Aygün
title	Identifying side effects of commonly used drugs in the treatment of Covid 19
title_short	Identifying side effects of commonly used drugs in the treatment of Covid 19
title_full	Identifying side effects of commonly used drugs in the treatment of Covid 19
title_fullStr	Identifying side effects of commonly used drugs in the treatment of Covid 19
title_full_unstemmed	Identifying side effects of commonly used drugs in the treatment of Covid 19
title_sort	identifying side effects of commonly used drugs in the treatment of covid 19
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b180765350b04456acc6e3f68515be48
work_keys_str_mv	AT irfanaygun identifyingsideeffectsofcommonlyuseddrugsinthetreatmentofcovid19 AT mehmetkaya identifyingsideeffectsofcommonlyuseddrugsinthetreatmentofcovid19 AT redaalhajj identifyingsideeffectsofcommonlyuseddrugsinthetreatmentofcovid19
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Identifying side effects of commonly used drugs in the treatment of Covid 19

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