Performance of body mass index and percentage of body fat in predicting cardiometabolic risk factors in Thai adults

Somlak Vanavanan,1 Pornpen Srisawasdi,1 Mana Rochanawutanon,2 Nalinee Kumproa,1 Khanat Kruthkul,3 Martin H Kroll4 1Division of Clinical Chemistry, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2National Healthcare Systems, Bangkok, Thailan...

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Autores principales:	Vanavanan S, Srisawasdi P, Rochanawutanon M, Kumproa N, Kruthkul K, Kroll MH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	obesity body mass index percentage of body fat Southeast Asian population cardiometabolic risk biomarkers obesity-related metabolic disorders. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/b180ed67080a4e7aa060d1b048d81bc8
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spelling	oai:doaj.org-article:b180ed67080a4e7aa060d1b048d81bc82021-12-02T06:20:06ZPerformance of body mass index and percentage of body fat in predicting cardiometabolic risk factors in Thai adults1178-7007https://doaj.org/article/b180ed67080a4e7aa060d1b048d81bc82018-06-01T00:00:00Zhttps://www.dovepress.com/performance-of-body-mass-index-and-percentage-of-body-fat-in-predictin-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Somlak Vanavanan,1 Pornpen Srisawasdi,1 Mana Rochanawutanon,2 Nalinee Kumproa,1 Khanat Kruthkul,3 Martin H Kroll4 1Division of Clinical Chemistry, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2National Healthcare Systems, Bangkok, Thailand; 3Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 4Quest Diagnostics, Madison, NJ, USA Background: Body mass index (BMI) and percentage of body fat (PBF) are used to measure obesity; however, their performance in identifying cardiometabolic risk in Southeast Asians is unclear. Generally, Asian women have higher PBF and lower BMI than do men and other ethnic populations. This study was conducted to address whether a discord exists between these measures in predicting obesity-related cardiometabolic risk in a Thai population and to test whether associations between the measures and risk factors for cardiovascular disease have a sex-specific inclination.Methods: A total of 234 (76 men and 158 women) outpatients were recruited. BMI obesity cutoff points were ≥25.0 and ≥27.0 kg/m2 and PBF cutoff points were ≥35.0% and ≥25.0% for women and men, respectively. Blood samples were analyzed for total cholesterol, triglycerides, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, lipoprotein subclasses, apolipoprotein A-I, apolipoprotein B, glucose, hemoglobin A1c, insulin, high-sensitive C-reactive protein (hsCRP), adiponectin, leptin, and 25-hydroxyvitamin D.Results: Twenty-five percent of participants classified as normal-BMI had excessive fat, whereas 9% classified as normal-PBF had excessive BMI. Good relationships were found between BMI and PBF using sex stratification (R2 >0.5). The prevalence of metabolic syndrome was markedly increased in overweight and/or excess body fat groups compared with lean group. Logistic regression analyses showed that BMI was the best predictor of hypertension. BMI was an independent predictor of insulin resistance, hyperglycemia, hypertriglyceridemia, and hyperleptinemia in women, whereas PBF was for men. However, PBF proved to be a good indicator for atherogenic lipoprotein particles in both sexes. Notably, neither index predicted increased hsCRP or 25-hydroxyvitamin D insufficiency.Conclusion: Considerable sex-specific variations were observed between BMI and PBF in their associations with and predictability of numerous cardiometabolic biomarkers. No single measure provides a comprehensive risk predication as shown herein with the Thai population, and therefore both should be applied in screening activities. Keywords: obesity, body mass index, percentage of body fat, Southeast Asian population, cardiometabolic risk biomarkers, obesity-related metabolic disordersVanavanan SSrisawasdi PRochanawutanon MKumproa NKruthkul KKroll MHDove Medical Pressarticleobesitybody mass indexpercentage of body fatSoutheast Asian populationcardiometabolic risk biomarkersobesity-related metabolic disorders.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 11, Pp 241-253 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity body mass index percentage of body fat Southeast Asian population cardiometabolic risk biomarkers obesity-related metabolic disorders. Specialties of internal medicine RC581-951
spellingShingle	obesity body mass index percentage of body fat Southeast Asian population cardiometabolic risk biomarkers obesity-related metabolic disorders. Specialties of internal medicine RC581-951 Vanavanan S Srisawasdi P Rochanawutanon M Kumproa N Kruthkul K Kroll MH Performance of body mass index and percentage of body fat in predicting cardiometabolic risk factors in Thai adults
description	Somlak Vanavanan,1 Pornpen Srisawasdi,1 Mana Rochanawutanon,2 Nalinee Kumproa,1 Khanat Kruthkul,3 Martin H Kroll4 1Division of Clinical Chemistry, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2National Healthcare Systems, Bangkok, Thailand; 3Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 4Quest Diagnostics, Madison, NJ, USA Background: Body mass index (BMI) and percentage of body fat (PBF) are used to measure obesity; however, their performance in identifying cardiometabolic risk in Southeast Asians is unclear. Generally, Asian women have higher PBF and lower BMI than do men and other ethnic populations. This study was conducted to address whether a discord exists between these measures in predicting obesity-related cardiometabolic risk in a Thai population and to test whether associations between the measures and risk factors for cardiovascular disease have a sex-specific inclination.Methods: A total of 234 (76 men and 158 women) outpatients were recruited. BMI obesity cutoff points were ≥25.0 and ≥27.0 kg/m2 and PBF cutoff points were ≥35.0% and ≥25.0% for women and men, respectively. Blood samples were analyzed for total cholesterol, triglycerides, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, lipoprotein subclasses, apolipoprotein A-I, apolipoprotein B, glucose, hemoglobin A1c, insulin, high-sensitive C-reactive protein (hsCRP), adiponectin, leptin, and 25-hydroxyvitamin D.Results: Twenty-five percent of participants classified as normal-BMI had excessive fat, whereas 9% classified as normal-PBF had excessive BMI. Good relationships were found between BMI and PBF using sex stratification (R2 >0.5). The prevalence of metabolic syndrome was markedly increased in overweight and/or excess body fat groups compared with lean group. Logistic regression analyses showed that BMI was the best predictor of hypertension. BMI was an independent predictor of insulin resistance, hyperglycemia, hypertriglyceridemia, and hyperleptinemia in women, whereas PBF was for men. However, PBF proved to be a good indicator for atherogenic lipoprotein particles in both sexes. Notably, neither index predicted increased hsCRP or 25-hydroxyvitamin D insufficiency.Conclusion: Considerable sex-specific variations were observed between BMI and PBF in their associations with and predictability of numerous cardiometabolic biomarkers. No single measure provides a comprehensive risk predication as shown herein with the Thai population, and therefore both should be applied in screening activities. Keywords: obesity, body mass index, percentage of body fat, Southeast Asian population, cardiometabolic risk biomarkers, obesity-related metabolic disorders
format	article
author	Vanavanan S Srisawasdi P Rochanawutanon M Kumproa N Kruthkul K Kroll MH
author_facet	Vanavanan S Srisawasdi P Rochanawutanon M Kumproa N Kruthkul K Kroll MH
author_sort	Vanavanan S
title	Performance of body mass index and percentage of body fat in predicting cardiometabolic risk factors in Thai adults
title_short	Performance of body mass index and percentage of body fat in predicting cardiometabolic risk factors in Thai adults
title_full	Performance of body mass index and percentage of body fat in predicting cardiometabolic risk factors in Thai adults
title_fullStr	Performance of body mass index and percentage of body fat in predicting cardiometabolic risk factors in Thai adults
title_full_unstemmed	Performance of body mass index and percentage of body fat in predicting cardiometabolic risk factors in Thai adults
title_sort	performance of body mass index and percentage of body fat in predicting cardiometabolic risk factors in thai adults
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/b180ed67080a4e7aa060d1b048d81bc8
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_version_	1718399956863156224

Performance of body mass index and percentage of body fat in predicting cardiometabolic risk factors in Thai adults

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