A single serving of mixed spices alters gut microflora composition: a dose–response randomised trial

Abstract Short-term changes in dietary intake can induce changes in gut microbiome. While various dietary polyphenols have been shown to modulate gut microflora, the acute influence of polyphenol-rich mixed spices has not been explored in a controlled setting. We investigated the effects of a single...

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Autores principales:	Wei Wei Thwe Khine, Sumanto Haldar, Shou De Loi, Yuan-Kun Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b1815c1e99814fa59b6a2ba2b553d06a
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spelling	oai:doaj.org-article:b1815c1e99814fa59b6a2ba2b553d06a2021-12-02T14:42:20ZA single serving of mixed spices alters gut microflora composition: a dose–response randomised trial10.1038/s41598-021-90453-72045-2322https://doaj.org/article/b1815c1e99814fa59b6a2ba2b553d06a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90453-7https://doaj.org/toc/2045-2322Abstract Short-term changes in dietary intake can induce changes in gut microbiome. While various dietary polyphenols have been shown to modulate gut microflora, the acute influence of polyphenol-rich mixed spices has not been explored in a controlled setting. We investigated the effects of a single serving of mixed spices Indian curry consumption, in two separate doses, on the gut microbiome in 15 healthy, Singaporean Chinese males, with age and BMI of 23.5 ± 2.4 years and 22.9 ± 2.2 kg/m2 respectively. We found that a low-polyphenol, no spices Dose 0 Control (D0C) meal led to an increase in Bacteroides and a decrease in Bifidobacterium. In comparison to D0C, there was significant suppression of Bacteroides (p < 0.05) and an increase in Bifidobacterium (p < 0.05) with increasing doses of curry meal Dose 1 Curry (D1C) and Dose 2 Curry (D2C) containing 6 g and 12 g mixed spices respectively. Significant correlations were also found between bacterial changes and plasma phenolic acids. No differences between treatments were observed in the alpha-diversity of the gut microflora. This study has shown that a single serving of mixed spices can significantly modify/restore certain commensal microbes, particularly in people who do not regularly consume these spices.Wei Wei Thwe KhineSumanto HaldarShou De LoiYuan-Kun LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei Wei Thwe Khine Sumanto Haldar Shou De Loi Yuan-Kun Lee A single serving of mixed spices alters gut microflora composition: a dose–response randomised trial
description	Abstract Short-term changes in dietary intake can induce changes in gut microbiome. While various dietary polyphenols have been shown to modulate gut microflora, the acute influence of polyphenol-rich mixed spices has not been explored in a controlled setting. We investigated the effects of a single serving of mixed spices Indian curry consumption, in two separate doses, on the gut microbiome in 15 healthy, Singaporean Chinese males, with age and BMI of 23.5 ± 2.4 years and 22.9 ± 2.2 kg/m2 respectively. We found that a low-polyphenol, no spices Dose 0 Control (D0C) meal led to an increase in Bacteroides and a decrease in Bifidobacterium. In comparison to D0C, there was significant suppression of Bacteroides (p < 0.05) and an increase in Bifidobacterium (p < 0.05) with increasing doses of curry meal Dose 1 Curry (D1C) and Dose 2 Curry (D2C) containing 6 g and 12 g mixed spices respectively. Significant correlations were also found between bacterial changes and plasma phenolic acids. No differences between treatments were observed in the alpha-diversity of the gut microflora. This study has shown that a single serving of mixed spices can significantly modify/restore certain commensal microbes, particularly in people who do not regularly consume these spices.
format	article
author	Wei Wei Thwe Khine Sumanto Haldar Shou De Loi Yuan-Kun Lee
author_facet	Wei Wei Thwe Khine Sumanto Haldar Shou De Loi Yuan-Kun Lee
author_sort	Wei Wei Thwe Khine
title	A single serving of mixed spices alters gut microflora composition: a dose–response randomised trial
title_short	A single serving of mixed spices alters gut microflora composition: a dose–response randomised trial
title_full	A single serving of mixed spices alters gut microflora composition: a dose–response randomised trial
title_fullStr	A single serving of mixed spices alters gut microflora composition: a dose–response randomised trial
title_full_unstemmed	A single serving of mixed spices alters gut microflora composition: a dose–response randomised trial
title_sort	single serving of mixed spices alters gut microflora composition: a dose–response randomised trial
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b1815c1e99814fa59b6a2ba2b553d06a
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A single serving of mixed spices alters gut microflora composition: a dose–response randomised trial

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