Loss of RNA expression and allele-specific expression associated with congenital heart disease

Congenital heart disease (CHD) is a disorder that occurs in ∼1% of live births. Here the authors describe a genome-wide allele-specific expression analyses in CHD patients, identifying five new genes involved in CHD and showing that paternally-expressed imprinted genes are monoallelic, while materna...

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Autores principales:	David M. McKean, Jason Homsy, Hiroko Wakimoto, Neil Patel, Joshua Gorham, Steven R. DePalma, James S. Ware, Samir Zaidi, Wenji Ma, Nihir Patel, Richard P. Lifton, Wendy K. Chung, Richard Kim, Yufeng Shen, Martina Brueckner, Elizabeth Goldmuntz, Andrew J. Sharp, Christine E. Seidman, Bruce D. Gelb, J. G. Seidman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b181fb4180d74c2d91f9090c30c74f4a
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spelling	oai:doaj.org-article:b181fb4180d74c2d91f9090c30c74f4a2021-12-02T15:35:19ZLoss of RNA expression and allele-specific expression associated with congenital heart disease10.1038/ncomms128242041-1723https://doaj.org/article/b181fb4180d74c2d91f9090c30c74f4a2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12824https://doaj.org/toc/2041-1723Congenital heart disease (CHD) is a disorder that occurs in ∼1% of live births. Here the authors describe a genome-wide allele-specific expression analyses in CHD patients, identifying five new genes involved in CHD and showing that paternally-expressed imprinted genes are monoallelic, while maternally-expressed imprinted genes are biallelic.David M. McKeanJason HomsyHiroko WakimotoNeil PatelJoshua GorhamSteven R. DePalmaJames S. WareSamir ZaidiWenji MaNihir PatelRichard P. LiftonWendy K. ChungRichard KimYufeng ShenMartina BruecknerElizabeth GoldmuntzAndrew J. SharpChristine E. SeidmanBruce D. GelbJ. G. SeidmanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David M. McKean Jason Homsy Hiroko Wakimoto Neil Patel Joshua Gorham Steven R. DePalma James S. Ware Samir Zaidi Wenji Ma Nihir Patel Richard P. Lifton Wendy K. Chung Richard Kim Yufeng Shen Martina Brueckner Elizabeth Goldmuntz Andrew J. Sharp Christine E. Seidman Bruce D. Gelb J. G. Seidman Loss of RNA expression and allele-specific expression associated with congenital heart disease
description	Congenital heart disease (CHD) is a disorder that occurs in ∼1% of live births. Here the authors describe a genome-wide allele-specific expression analyses in CHD patients, identifying five new genes involved in CHD and showing that paternally-expressed imprinted genes are monoallelic, while maternally-expressed imprinted genes are biallelic.
format	article
author	David M. McKean Jason Homsy Hiroko Wakimoto Neil Patel Joshua Gorham Steven R. DePalma James S. Ware Samir Zaidi Wenji Ma Nihir Patel Richard P. Lifton Wendy K. Chung Richard Kim Yufeng Shen Martina Brueckner Elizabeth Goldmuntz Andrew J. Sharp Christine E. Seidman Bruce D. Gelb J. G. Seidman
author_facet	David M. McKean Jason Homsy Hiroko Wakimoto Neil Patel Joshua Gorham Steven R. DePalma James S. Ware Samir Zaidi Wenji Ma Nihir Patel Richard P. Lifton Wendy K. Chung Richard Kim Yufeng Shen Martina Brueckner Elizabeth Goldmuntz Andrew J. Sharp Christine E. Seidman Bruce D. Gelb J. G. Seidman
author_sort	David M. McKean
title	Loss of RNA expression and allele-specific expression associated with congenital heart disease
title_short	Loss of RNA expression and allele-specific expression associated with congenital heart disease
title_full	Loss of RNA expression and allele-specific expression associated with congenital heart disease
title_fullStr	Loss of RNA expression and allele-specific expression associated with congenital heart disease
title_full_unstemmed	Loss of RNA expression and allele-specific expression associated with congenital heart disease
title_sort	loss of rna expression and allele-specific expression associated with congenital heart disease
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b181fb4180d74c2d91f9090c30c74f4a
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Loss of RNA expression and allele-specific expression associated with congenital heart disease

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