Intermediate Uveitis Etiology, Complications, Treatment, and Outcomes in a Colombian Uveitis Referral Center

William Rojas-Carabali,1,* Juliana Reyes-Guanes,2,* Valeria Villabona-Martinez,1 Maria Alejandra Fonseca-Mora,1 Alejandra de-la-Torre1 1Neuroscience Research Group “NeURos”, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia; 2Escuela...

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Autores principales:	Rojas-Carabali W, Reyes-Guanes J, Villabona-Martinez V, Fonseca-Mora MA, de-la-Torre A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	ocular inflammatory diseases uveitis epidemiology etiology colombia. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/b1890ca4fba44cdb9e2ae828e0cde243
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spelling	oai:doaj.org-article:b1890ca4fba44cdb9e2ae828e0cde2432021-12-02T16:07:16ZIntermediate Uveitis Etiology, Complications, Treatment, and Outcomes in a Colombian Uveitis Referral Center1177-5483https://doaj.org/article/b1890ca4fba44cdb9e2ae828e0cde2432021-06-01T00:00:00Zhttps://www.dovepress.com/intermediate-uveitis-etiology-complications-treatment-and-outcomes-in--peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483William Rojas-Carabali,1,* Juliana Reyes-Guanes,2,* Valeria Villabona-Martinez,1 Maria Alejandra Fonseca-Mora,1 Alejandra de-la-Torre1 1Neuroscience Research Group “NeURos”, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia; 2Escuela Barraquer Research Group, Escuela Superior de Oftalmología del Instituto Barraquer de América, Bogotá, Colombia*These authors contributed equally to this workCorrespondence: Alejandra de-la-TorreNeuroscience Research Group “NeURos”, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Carrera 24 # 63C - 69, Bogotá, ColombiaTel +57 3102482196Email alejadelatorre@yahoo.comPurpose: To analyze the etiology, clinical characteristics, complications, treatments, and outcomes of patients with intermediate uveitis examined in a uveitis referral center in Bogotá, Colombia.Patients and Methods: We conducted a retrospective descriptive study. We reviewed systematically the clinical records of patients attending a uveitis referral center in Bogotá, Colombia from 2013 to 2020. Data analysis included demographics, etiology, clinical characteristics, treatment modalities, best-corrected visual acuity, and complications. For categorical variables, absolute and relative frequencies were used while for continuous variables mean and standard deviations were calculated.Results: We identified 18 patients with intermediate uveitis. The mean age at disease onset was 19.4 years. There was no sex predominance. Two-thirds of the patients presented bilateral involvement. The mean initial best-corrected visual acuity was 0.19 LogMAR. The most common etiology was idiopathic followed by undetermined, tuberculosis, multiple sclerosis, and juvenile idiopathic arthritis. The most common characteristics were insidious onset, chronic course, and persistent duration. The complications found were macular edema, optic disk edema, cataract, epiretinal membrane, among others. Corticosteroids and immunosuppressive therapy were the most common treatments. Mean follow-up time was 24.4 months, and the mean final best-corrected visual acuity was 0.12 LogMAR.Conclusion: This is the first study describing intermediate uveitis features in South America. In our context, intermediate uveitis is infrequent. Polyautoimmunity and familial autoimmunity phenomena were found in some patients. These may require a multidisciplinary approach. Ophthalmologists should promptly diagnose, treat, and refer patients with this disease to avoid common complications. Further studies are required to determine the disease relation with polyautoimmunity.Keywords: ocular inflammatory diseases, uveitis, epidemiology, etiology, ColombiaRojas-Carabali WReyes-Guanes JVillabona-Martinez VFonseca-Mora MAde-la-Torre ADove Medical Pressarticleocular inflammatory diseasesuveitisepidemiologyetiologycolombia.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 2597-2605 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ocular inflammatory diseases uveitis epidemiology etiology colombia. Ophthalmology RE1-994
spellingShingle	ocular inflammatory diseases uveitis epidemiology etiology colombia. Ophthalmology RE1-994 Rojas-Carabali W Reyes-Guanes J Villabona-Martinez V Fonseca-Mora MA de-la-Torre A Intermediate Uveitis Etiology, Complications, Treatment, and Outcomes in a Colombian Uveitis Referral Center
description	William Rojas-Carabali,1,* Juliana Reyes-Guanes,2,* Valeria Villabona-Martinez,1 Maria Alejandra Fonseca-Mora,1 Alejandra de-la-Torre1 1Neuroscience Research Group “NeURos”, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia; 2Escuela Barraquer Research Group, Escuela Superior de Oftalmología del Instituto Barraquer de América, Bogotá, Colombia*These authors contributed equally to this workCorrespondence: Alejandra de-la-TorreNeuroscience Research Group “NeURos”, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Carrera 24 # 63C - 69, Bogotá, ColombiaTel +57 3102482196Email alejadelatorre@yahoo.comPurpose: To analyze the etiology, clinical characteristics, complications, treatments, and outcomes of patients with intermediate uveitis examined in a uveitis referral center in Bogotá, Colombia.Patients and Methods: We conducted a retrospective descriptive study. We reviewed systematically the clinical records of patients attending a uveitis referral center in Bogotá, Colombia from 2013 to 2020. Data analysis included demographics, etiology, clinical characteristics, treatment modalities, best-corrected visual acuity, and complications. For categorical variables, absolute and relative frequencies were used while for continuous variables mean and standard deviations were calculated.Results: We identified 18 patients with intermediate uveitis. The mean age at disease onset was 19.4 years. There was no sex predominance. Two-thirds of the patients presented bilateral involvement. The mean initial best-corrected visual acuity was 0.19 LogMAR. The most common etiology was idiopathic followed by undetermined, tuberculosis, multiple sclerosis, and juvenile idiopathic arthritis. The most common characteristics were insidious onset, chronic course, and persistent duration. The complications found were macular edema, optic disk edema, cataract, epiretinal membrane, among others. Corticosteroids and immunosuppressive therapy were the most common treatments. Mean follow-up time was 24.4 months, and the mean final best-corrected visual acuity was 0.12 LogMAR.Conclusion: This is the first study describing intermediate uveitis features in South America. In our context, intermediate uveitis is infrequent. Polyautoimmunity and familial autoimmunity phenomena were found in some patients. These may require a multidisciplinary approach. Ophthalmologists should promptly diagnose, treat, and refer patients with this disease to avoid common complications. Further studies are required to determine the disease relation with polyautoimmunity.Keywords: ocular inflammatory diseases, uveitis, epidemiology, etiology, Colombia
format	article
author	Rojas-Carabali W Reyes-Guanes J Villabona-Martinez V Fonseca-Mora MA de-la-Torre A
author_facet	Rojas-Carabali W Reyes-Guanes J Villabona-Martinez V Fonseca-Mora MA de-la-Torre A
author_sort	Rojas-Carabali W
title	Intermediate Uveitis Etiology, Complications, Treatment, and Outcomes in a Colombian Uveitis Referral Center
title_short	Intermediate Uveitis Etiology, Complications, Treatment, and Outcomes in a Colombian Uveitis Referral Center
title_full	Intermediate Uveitis Etiology, Complications, Treatment, and Outcomes in a Colombian Uveitis Referral Center
title_fullStr	Intermediate Uveitis Etiology, Complications, Treatment, and Outcomes in a Colombian Uveitis Referral Center
title_full_unstemmed	Intermediate Uveitis Etiology, Complications, Treatment, and Outcomes in a Colombian Uveitis Referral Center
title_sort	intermediate uveitis etiology, complications, treatment, and outcomes in a colombian uveitis referral center
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/b1890ca4fba44cdb9e2ae828e0cde243
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Intermediate Uveitis Etiology, Complications, Treatment, and Outcomes in a Colombian Uveitis Referral Center

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