Malaria Induces Anemia through CD8<sup>+</sup> T Cell-Dependent Parasite Clearance and Erythrocyte Removal in the Spleen

Malaria Induces Anemia through CD8<sup>+</sup> T Cell-Dependent Parasite Clearance and Erythrocyte Removal in the Spleen

ABSTRACT  Severe malarial anemia (SMA) in semi-immune individuals eliminates both infected and uninfected erythrocytes and is a frequent fatal complication. It is proportional not to circulating parasitemia but total parasite mass (sequestered) in the organs. Thus, immune responses that clear parasi...

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Main Authors: Innocent Safeukui, Noé D. Gomez, Aanuoluwa A. Adelani, Florence Burte, Nathaniel K. Afolabi, Rama Akondy, Peter Velazquez, Anthony Holder, Rita Tewari, Pierre Buffet, Biobele J. Brown, Wuraola A. Shokunbi, David Olaleye, Olugbemiro Sodeinde, James Kazura, Rafi Ahmed, Narla Mohandas, Delmiro Fernandez-Reyes, Kasturi Haldar
Format: article
Language:EN
Published: American Society for Microbiology 2015
Subjects:
Microbiology
QR1-502
Online Access:https://doaj.org/article/b18bccfedc1f46e3a03ecd402fa15bf1
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https://doaj.org/article/b18bccfedc1f46e3a03ecd402fa15bf1

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