Iron supplementation regulates the progression of high fat diet induced obesity and hepatic steatosis via mitochondrial signaling pathways

Abstract Disruption of iron metabolism is closely related to metabolic diseases. Iron deficiency is frequently associated with obesity and hepatic steatosis. However, the effects of iron supplementation on obesity and energy metabolism remain unclear. Here we show that a high-fat diet supplemented w...

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Autores principales:	Naho Kitamura, Yoko Yokoyama, Hiroki Taoka, Utana Nagano, Shotaro Hosoda, Tanon Taworntawat, Anna Nakamura, Yoko Ogawa, Kazuo Tsubota, Mitsuhiro Watanabe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b19453f8f4d1406086545e36a6a1646c
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spelling	oai:doaj.org-article:b19453f8f4d1406086545e36a6a1646c2021-12-02T15:49:28ZIron supplementation regulates the progression of high fat diet induced obesity and hepatic steatosis via mitochondrial signaling pathways10.1038/s41598-021-89673-82045-2322https://doaj.org/article/b19453f8f4d1406086545e36a6a1646c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89673-8https://doaj.org/toc/2045-2322Abstract Disruption of iron metabolism is closely related to metabolic diseases. Iron deficiency is frequently associated with obesity and hepatic steatosis. However, the effects of iron supplementation on obesity and energy metabolism remain unclear. Here we show that a high-fat diet supplemented with iron reduces body weight gain and hepatic lipid accumulation in mice. Iron supplementation was found to reduce mitochondrial morphological abnormalities and upregulate gene transcription involved in mitochondrial function and beta oxidation in the liver and skeletal muscle. In both these tissues, iron supplementation increased the expression of genes involved in heme or iron–sulfur (Fe–S) cluster synthesis. Heme and Fe–S cluster, which are iron prosthetic groups contained in electron transport chain complex subunits, are essential for mitochondrial respiration. The findings of this study demonstrated that iron regulates mitochondrial signaling pathways—gene transcription of mitochondrial component molecules synthesis and their energy metabolism. Overall, the study elucidates the molecular basis underlying the relationship between iron supplementation and obesity and hepatic steatosis progression, and the role of iron as a signaling molecule.Naho KitamuraYoko YokoyamaHiroki TaokaUtana NaganoShotaro HosodaTanon TaworntawatAnna NakamuraYoko OgawaKazuo TsubotaMitsuhiro WatanabeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Naho Kitamura Yoko Yokoyama Hiroki Taoka Utana Nagano Shotaro Hosoda Tanon Taworntawat Anna Nakamura Yoko Ogawa Kazuo Tsubota Mitsuhiro Watanabe Iron supplementation regulates the progression of high fat diet induced obesity and hepatic steatosis via mitochondrial signaling pathways
description	Abstract Disruption of iron metabolism is closely related to metabolic diseases. Iron deficiency is frequently associated with obesity and hepatic steatosis. However, the effects of iron supplementation on obesity and energy metabolism remain unclear. Here we show that a high-fat diet supplemented with iron reduces body weight gain and hepatic lipid accumulation in mice. Iron supplementation was found to reduce mitochondrial morphological abnormalities and upregulate gene transcription involved in mitochondrial function and beta oxidation in the liver and skeletal muscle. In both these tissues, iron supplementation increased the expression of genes involved in heme or iron–sulfur (Fe–S) cluster synthesis. Heme and Fe–S cluster, which are iron prosthetic groups contained in electron transport chain complex subunits, are essential for mitochondrial respiration. The findings of this study demonstrated that iron regulates mitochondrial signaling pathways—gene transcription of mitochondrial component molecules synthesis and their energy metabolism. Overall, the study elucidates the molecular basis underlying the relationship between iron supplementation and obesity and hepatic steatosis progression, and the role of iron as a signaling molecule.
format	article
author	Naho Kitamura Yoko Yokoyama Hiroki Taoka Utana Nagano Shotaro Hosoda Tanon Taworntawat Anna Nakamura Yoko Ogawa Kazuo Tsubota Mitsuhiro Watanabe
author_facet	Naho Kitamura Yoko Yokoyama Hiroki Taoka Utana Nagano Shotaro Hosoda Tanon Taworntawat Anna Nakamura Yoko Ogawa Kazuo Tsubota Mitsuhiro Watanabe
author_sort	Naho Kitamura
title	Iron supplementation regulates the progression of high fat diet induced obesity and hepatic steatosis via mitochondrial signaling pathways
title_short	Iron supplementation regulates the progression of high fat diet induced obesity and hepatic steatosis via mitochondrial signaling pathways
title_full	Iron supplementation regulates the progression of high fat diet induced obesity and hepatic steatosis via mitochondrial signaling pathways
title_fullStr	Iron supplementation regulates the progression of high fat diet induced obesity and hepatic steatosis via mitochondrial signaling pathways
title_full_unstemmed	Iron supplementation regulates the progression of high fat diet induced obesity and hepatic steatosis via mitochondrial signaling pathways
title_sort	iron supplementation regulates the progression of high fat diet induced obesity and hepatic steatosis via mitochondrial signaling pathways
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b19453f8f4d1406086545e36a6a1646c
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Iron supplementation regulates the progression of high fat diet induced obesity and hepatic steatosis via mitochondrial signaling pathways

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