A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages

IFNy can polarize macrophages in the tumour microenvironment to an inflammatory state and thereby contributes to their anti-tumour function. Here the authors show an underlying mechanism in this process is IFNy-driven STAT1 occupancy and activation of NRE1, a regulatory region within the NAMPT gene,...

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Autores principales:	Thomas B. Huffaker, H. Atakan Ekiz, Cindy Barba, Soh-Hyun Lee, Marah C. Runtsch, Morgan C. Nelson, Kaylyn M. Bauer, William W. Tang, Timothy L. Mosbruger, James E. Cox, June L. Round, Warren P. Voth, Ryan M. O’Connell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b194e57208eb4a39a01b6f84ed5db4cc
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spelling	oai:doaj.org-article:b194e57208eb4a39a01b6f84ed5db4cc2021-12-02T14:35:39ZA Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages10.1038/s41467-021-22923-52041-1723https://doaj.org/article/b194e57208eb4a39a01b6f84ed5db4cc2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22923-5https://doaj.org/toc/2041-1723IFNy can polarize macrophages in the tumour microenvironment to an inflammatory state and thereby contributes to their anti-tumour function. Here the authors show an underlying mechanism in this process is IFNy-driven STAT1 occupancy and activation of NRE1, a regulatory region within the NAMPT gene, thereby implicating inducible NAD salvage synthesis in TAM functions.Thomas B. HuffakerH. Atakan EkizCindy BarbaSoh-Hyun LeeMarah C. RuntschMorgan C. NelsonKaylyn M. BauerWilliam W. TangTimothy L. MosbrugerJames E. CoxJune L. RoundWarren P. VothRyan M. O’ConnellNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas B. Huffaker H. Atakan Ekiz Cindy Barba Soh-Hyun Lee Marah C. Runtsch Morgan C. Nelson Kaylyn M. Bauer William W. Tang Timothy L. Mosbruger James E. Cox June L. Round Warren P. Voth Ryan M. O’Connell A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages
description	IFNy can polarize macrophages in the tumour microenvironment to an inflammatory state and thereby contributes to their anti-tumour function. Here the authors show an underlying mechanism in this process is IFNy-driven STAT1 occupancy and activation of NRE1, a regulatory region within the NAMPT gene, thereby implicating inducible NAD salvage synthesis in TAM functions.
format	article
author	Thomas B. Huffaker H. Atakan Ekiz Cindy Barba Soh-Hyun Lee Marah C. Runtsch Morgan C. Nelson Kaylyn M. Bauer William W. Tang Timothy L. Mosbruger James E. Cox June L. Round Warren P. Voth Ryan M. O’Connell
author_facet	Thomas B. Huffaker H. Atakan Ekiz Cindy Barba Soh-Hyun Lee Marah C. Runtsch Morgan C. Nelson Kaylyn M. Bauer William W. Tang Timothy L. Mosbruger James E. Cox June L. Round Warren P. Voth Ryan M. O’Connell
author_sort	Thomas B. Huffaker
title	A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages
title_short	A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages
title_full	A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages
title_fullStr	A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages
title_full_unstemmed	A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages
title_sort	stat1 bound enhancer promotes nampt expression and function within tumor associated macrophages
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b194e57208eb4a39a01b6f84ed5db4cc
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A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages

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