A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages

A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages

IFNy can polarize macrophages in the tumour microenvironment to an inflammatory state and thereby contributes to their anti-tumour function. Here the authors show an underlying mechanism in this process is IFNy-driven STAT1 occupancy and activation of NRE1, a regulatory region within the NAMPT gene,...

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Main Authors: Thomas B. Huffaker, H. Atakan Ekiz, Cindy Barba, Soh-Hyun Lee, Marah C. Runtsch, Morgan C. Nelson, Kaylyn M. Bauer, William W. Tang, Timothy L. Mosbruger, James E. Cox, June L. Round, Warren P. Voth, Ryan M. O’Connell
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/b194e57208eb4a39a01b6f84ed5db4cc
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https://doaj.org/article/b194e57208eb4a39a01b6f84ed5db4cc

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