Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study

Abstract The change in maternal lipid, leptin and adiponectin concentrations during pregnancy and infant birth weight (BW) is still poorly characterized. Thus, the aim of the study was to evaluate the association of maternal lipids, leptin and adiponectin throughout pregnancy with large-for-gestatio...

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Autores principales:	Dayana Rodrigues Farias, Lucilla Poston, Ana Beatriz Franco-Sena, Antônio Augusto Moura da Silva, Thatiana Pinto, Lívia Costa de Oliveira, Gilberto Kac
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b197ebef214849aca2ea865c1823df2c
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spelling	oai:doaj.org-article:b197ebef214849aca2ea865c1823df2c2021-12-02T11:41:09ZMaternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study10.1038/s41598-017-00941-y2045-2322https://doaj.org/article/b197ebef214849aca2ea865c1823df2c2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00941-yhttps://doaj.org/toc/2045-2322Abstract The change in maternal lipid, leptin and adiponectin concentrations during pregnancy and infant birth weight (BW) is still poorly characterized. Thus, the aim of the study was to evaluate the association of maternal lipids, leptin and adiponectin throughout pregnancy with large-for-gestational-age (LGA) births and BW z-score. A prospective cohort of 199 mothers was followed during pregnancy in Rio de Janeiro, Brazil. The statistical analyses comprised multiple logistic and linear regression. Women delivered 36 LGA and 11 small-for-gestational-age newborns. HDL-c rate of change throughout pregnancy was negatively associated with BW z-score (β = −1.99; p = 0.003) and the delivery of a LGA newborn (OR = 0.02; p = 0.043). Pregnancy baseline concentration of log leptin was positively associated (OR = 3.92; p = 0.025) with LGA births. LDL-c rate of change throughout pregnancy was positively associated with BW z-score (β = 0.31; p = 0.004). Log triglycerides and log adiponectin were not significantly associated with BW z-score or LGA birth. In conclusion, a higher log leptin pregnancy baseline concentration and a lower HDL-c rate of change during pregnancy were associated with higher odds of having a LGA newborn. These maternal biomarkers are important to foetal growth and could be used in prenatal care as an additional strategy to screen women at risk of inadequate BW.Dayana Rodrigues FariasLucilla PostonAna Beatriz Franco-SenaAntônio Augusto Moura da SilvaThatiana PintoLívia Costa de OliveiraGilberto KacNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dayana Rodrigues Farias Lucilla Poston Ana Beatriz Franco-Sena Antônio Augusto Moura da Silva Thatiana Pinto Lívia Costa de Oliveira Gilberto Kac Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study
description	Abstract The change in maternal lipid, leptin and adiponectin concentrations during pregnancy and infant birth weight (BW) is still poorly characterized. Thus, the aim of the study was to evaluate the association of maternal lipids, leptin and adiponectin throughout pregnancy with large-for-gestational-age (LGA) births and BW z-score. A prospective cohort of 199 mothers was followed during pregnancy in Rio de Janeiro, Brazil. The statistical analyses comprised multiple logistic and linear regression. Women delivered 36 LGA and 11 small-for-gestational-age newborns. HDL-c rate of change throughout pregnancy was negatively associated with BW z-score (β = −1.99; p = 0.003) and the delivery of a LGA newborn (OR = 0.02; p = 0.043). Pregnancy baseline concentration of log leptin was positively associated (OR = 3.92; p = 0.025) with LGA births. LDL-c rate of change throughout pregnancy was positively associated with BW z-score (β = 0.31; p = 0.004). Log triglycerides and log adiponectin were not significantly associated with BW z-score or LGA birth. In conclusion, a higher log leptin pregnancy baseline concentration and a lower HDL-c rate of change during pregnancy were associated with higher odds of having a LGA newborn. These maternal biomarkers are important to foetal growth and could be used in prenatal care as an additional strategy to screen women at risk of inadequate BW.
format	article
author	Dayana Rodrigues Farias Lucilla Poston Ana Beatriz Franco-Sena Antônio Augusto Moura da Silva Thatiana Pinto Lívia Costa de Oliveira Gilberto Kac
author_facet	Dayana Rodrigues Farias Lucilla Poston Ana Beatriz Franco-Sena Antônio Augusto Moura da Silva Thatiana Pinto Lívia Costa de Oliveira Gilberto Kac
author_sort	Dayana Rodrigues Farias
title	Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study
title_short	Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study
title_full	Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study
title_fullStr	Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study
title_full_unstemmed	Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study
title_sort	maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b197ebef214849aca2ea865c1823df2c
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Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study

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