Malignant Pleural Mesothelioma Nodal Status: Where Are We at?

Due to the lack of both prospective trial and high-volume retrospective studies, the management of clinical N+ malignant pleural mesothelioma (MPM) patients remains highly debated. Node positive patients show poor survival compared with node-negative ones; thus, lymph node staging appears crucial in...

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Autores principales:	Sara Ricciardi, Francesco Carleo, Massimo O. Jaus, Marco Di Martino, Luigi Carbone, Alberto Ricci, Giuseppe Cardillo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	malignant pleura mesothelioma node positive MPM staging surgery prognostic factors Medicine R
Acceso en línea:	https://doaj.org/article/b19da1ba6c4f479ca290b86230e90ba0
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id	oai:doaj.org-article:b19da1ba6c4f479ca290b86230e90ba0
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spelling	oai:doaj.org-article:b19da1ba6c4f479ca290b86230e90ba02021-11-11T17:47:27ZMalignant Pleural Mesothelioma Nodal Status: Where Are We at?10.3390/jcm102151772077-0383https://doaj.org/article/b19da1ba6c4f479ca290b86230e90ba02021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5177https://doaj.org/toc/2077-0383Due to the lack of both prospective trial and high-volume retrospective studies, the management of clinical N+ malignant pleural mesothelioma (MPM) patients remains highly debated. Node positive patients show poor survival compared with node-negative ones; thus, lymph node staging appears crucial in determining treatment strategy. Notwithstanding the improvement in pre-treatment staging and the update on lymph node classification in the 8th edition of TNM, several open controversies remain on N parameter. How should we stage suspected N+ patients? How should we treat node positive patients? Which is the definition of a “resectable patient”? Is the site or the number the main prognostic factor for node positive patients? The aim of our narrative review is to analyse the existing relevant literature on lymph node status in MPM.Sara RicciardiFrancesco CarleoMassimo O. JausMarco Di MartinoLuigi CarboneAlberto RicciGiuseppe CardilloMDPI AGarticlemalignant pleura mesotheliomanode positive MPMstagingsurgeryprognostic factorsMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5177, p 5177 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	malignant pleura mesothelioma node positive MPM staging surgery prognostic factors Medicine R
spellingShingle	malignant pleura mesothelioma node positive MPM staging surgery prognostic factors Medicine R Sara Ricciardi Francesco Carleo Massimo O. Jaus Marco Di Martino Luigi Carbone Alberto Ricci Giuseppe Cardillo Malignant Pleural Mesothelioma Nodal Status: Where Are We at?
description	Due to the lack of both prospective trial and high-volume retrospective studies, the management of clinical N+ malignant pleural mesothelioma (MPM) patients remains highly debated. Node positive patients show poor survival compared with node-negative ones; thus, lymph node staging appears crucial in determining treatment strategy. Notwithstanding the improvement in pre-treatment staging and the update on lymph node classification in the 8th edition of TNM, several open controversies remain on N parameter. How should we stage suspected N+ patients? How should we treat node positive patients? Which is the definition of a “resectable patient”? Is the site or the number the main prognostic factor for node positive patients? The aim of our narrative review is to analyse the existing relevant literature on lymph node status in MPM.
format	article
author	Sara Ricciardi Francesco Carleo Massimo O. Jaus Marco Di Martino Luigi Carbone Alberto Ricci Giuseppe Cardillo
author_facet	Sara Ricciardi Francesco Carleo Massimo O. Jaus Marco Di Martino Luigi Carbone Alberto Ricci Giuseppe Cardillo
author_sort	Sara Ricciardi
title	Malignant Pleural Mesothelioma Nodal Status: Where Are We at?
title_short	Malignant Pleural Mesothelioma Nodal Status: Where Are We at?
title_full	Malignant Pleural Mesothelioma Nodal Status: Where Are We at?
title_fullStr	Malignant Pleural Mesothelioma Nodal Status: Where Are We at?
title_full_unstemmed	Malignant Pleural Mesothelioma Nodal Status: Where Are We at?
title_sort	malignant pleural mesothelioma nodal status: where are we at?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b19da1ba6c4f479ca290b86230e90ba0
work_keys_str_mv	AT sararicciardi malignantpleuralmesotheliomanodalstatuswhereareweat AT francescocarleo malignantpleuralmesotheliomanodalstatuswhereareweat AT massimoojaus malignantpleuralmesotheliomanodalstatuswhereareweat AT marcodimartino malignantpleuralmesotheliomanodalstatuswhereareweat AT luigicarbone malignantpleuralmesotheliomanodalstatuswhereareweat AT albertoricci malignantpleuralmesotheliomanodalstatuswhereareweat AT giuseppecardillo malignantpleuralmesotheliomanodalstatuswhereareweat
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Malignant Pleural Mesothelioma Nodal Status: Where Are We at?

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