Serum Corin Level Is Associated With Subsequent Decline in Renal Function in Patients With Suspected Coronary Artery Disease

BackgroundHigher circulatory corin in patients with cardiac diseases is associated with improved cardiovascular outcomes, and chronic cardiac dysfunction is a well‐known cause of progressive renal dysfunction. This study aimed to determine the role of serum corin in predicting short‐term and long‐te...

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Autores principales:	Shang‐Feng Yang, Ruey‐Hsing Chou, Szu‐Yuan Li, Shao‐Sung Huang, Po‐Hsun Huang
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2018
Materias:	chronic kidney disease contrast‐induced nephropathy corin diagnosis coronary angiography Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/b19e5d0311de48a9b54764004b8f7d9e
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spelling	oai:doaj.org-article:b19e5d0311de48a9b54764004b8f7d9e2021-11-12T17:01:48ZSerum Corin Level Is Associated With Subsequent Decline in Renal Function in Patients With Suspected Coronary Artery Disease10.1161/JAHA.117.0081572047-9980https://doaj.org/article/b19e5d0311de48a9b54764004b8f7d9e2018-05-01T00:00:00Zhttps://www.ahajournals.org/doi/10.1161/JAHA.117.008157https://doaj.org/toc/2047-9980BackgroundHigher circulatory corin in patients with cardiac diseases is associated with improved cardiovascular outcomes, and chronic cardiac dysfunction is a well‐known cause of progressive renal dysfunction. This study aimed to determine the role of serum corin in predicting short‐term and long‐term renal outcomes after contrast exposure in patients with suspected coronary artery disease. Methods and ResultsFour hundred one patients who had received coronary angiography were enrolled. Serum corin levels were determined before administration of contrast media. Contrast‐induced nephropathy was defined as a rise in serum creatinine of 0.5 mg/dL or a 25% increase from baseline within 48 hours after the procedure. Progressive renal dysfunction was defined as >50% decrease in estimated glomerular filtration rate after discharge. All patients were followed up for at least 1 year or until the occurrence of death after coronary angiography. Overall, contrast‐induced nephropathy occurred in 23 (5.7%) patients. During a median follow‐up of 529 days, 44 (11.0%) cases had subsequent decline in renal function. After adjustment for demographic characteristics, kidney function, traditional risk factors, and medications, lower corin level was found to be independently associated with higher risk for progressive renal dysfunction (hazard ratio, 0.23; 95% confidence interval, 0.12–0.44) but not for contrast‐induced nephropathy. This inverse correlation remained evident in patients with underlying chronic kidney disease, coronary artery disease, or heart failure. ConclusionsLower baseline serum corin was associated with higher risk of renal function decline in patients undergoing coronary angiography. Further studies are needed to verify these results.Shang‐Feng YangRuey‐Hsing ChouSzu‐Yuan LiShao‐Sung HuangPo‐Hsun HuangWileyarticlechronic kidney diseasecontrast‐induced nephropathycorin diagnosiscoronary angiographyDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic kidney disease contrast‐induced nephropathy corin diagnosis coronary angiography Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	chronic kidney disease contrast‐induced nephropathy corin diagnosis coronary angiography Diseases of the circulatory (Cardiovascular) system RC666-701 Shang‐Feng Yang Ruey‐Hsing Chou Szu‐Yuan Li Shao‐Sung Huang Po‐Hsun Huang Serum Corin Level Is Associated With Subsequent Decline in Renal Function in Patients With Suspected Coronary Artery Disease
description	BackgroundHigher circulatory corin in patients with cardiac diseases is associated with improved cardiovascular outcomes, and chronic cardiac dysfunction is a well‐known cause of progressive renal dysfunction. This study aimed to determine the role of serum corin in predicting short‐term and long‐term renal outcomes after contrast exposure in patients with suspected coronary artery disease. Methods and ResultsFour hundred one patients who had received coronary angiography were enrolled. Serum corin levels were determined before administration of contrast media. Contrast‐induced nephropathy was defined as a rise in serum creatinine of 0.5 mg/dL or a 25% increase from baseline within 48 hours after the procedure. Progressive renal dysfunction was defined as >50% decrease in estimated glomerular filtration rate after discharge. All patients were followed up for at least 1 year or until the occurrence of death after coronary angiography. Overall, contrast‐induced nephropathy occurred in 23 (5.7%) patients. During a median follow‐up of 529 days, 44 (11.0%) cases had subsequent decline in renal function. After adjustment for demographic characteristics, kidney function, traditional risk factors, and medications, lower corin level was found to be independently associated with higher risk for progressive renal dysfunction (hazard ratio, 0.23; 95% confidence interval, 0.12–0.44) but not for contrast‐induced nephropathy. This inverse correlation remained evident in patients with underlying chronic kidney disease, coronary artery disease, or heart failure. ConclusionsLower baseline serum corin was associated with higher risk of renal function decline in patients undergoing coronary angiography. Further studies are needed to verify these results.
format	article
author	Shang‐Feng Yang Ruey‐Hsing Chou Szu‐Yuan Li Shao‐Sung Huang Po‐Hsun Huang
author_facet	Shang‐Feng Yang Ruey‐Hsing Chou Szu‐Yuan Li Shao‐Sung Huang Po‐Hsun Huang
author_sort	Shang‐Feng Yang
title	Serum Corin Level Is Associated With Subsequent Decline in Renal Function in Patients With Suspected Coronary Artery Disease
title_short	Serum Corin Level Is Associated With Subsequent Decline in Renal Function in Patients With Suspected Coronary Artery Disease
title_full	Serum Corin Level Is Associated With Subsequent Decline in Renal Function in Patients With Suspected Coronary Artery Disease
title_fullStr	Serum Corin Level Is Associated With Subsequent Decline in Renal Function in Patients With Suspected Coronary Artery Disease
title_full_unstemmed	Serum Corin Level Is Associated With Subsequent Decline in Renal Function in Patients With Suspected Coronary Artery Disease
title_sort	serum corin level is associated with subsequent decline in renal function in patients with suspected coronary artery disease
publisher	Wiley
publishDate	2018
url	https://doaj.org/article/b19e5d0311de48a9b54764004b8f7d9e
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Serum Corin Level Is Associated With Subsequent Decline in Renal Function in Patients With Suspected Coronary Artery Disease

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