Development of a rat capnoperitoneum phantom to study drug aerosol deposition in the context of anticancer research on peritoneal carcinomatosis

Abstract Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a promising approach with a high optimization potential for the treatment of peritoneal carcinomatosis. To study the efficacy of PIPAC and drugs, first rodent cancer models were developed. But inefficient drug aerosol supply and kn...

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Autores principales:	Daniel Göhler, Antje Geldner, Ralf Gritzki, Franz Lohse, Stephan Große, Julien Sobilo, Clemens Felsmann, Jonathan R. Buggisch, Alain Le Pape, Andreas Rudolph, Michael Stintz, Urs Giger-Pabst
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b1a0f240eea44bb2911eaa2667ca4356
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spelling	oai:doaj.org-article:b1a0f240eea44bb2911eaa2667ca43562021-11-14T12:19:26ZDevelopment of a rat capnoperitoneum phantom to study drug aerosol deposition in the context of anticancer research on peritoneal carcinomatosis10.1038/s41598-021-01332-02045-2322https://doaj.org/article/b1a0f240eea44bb2911eaa2667ca43562021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01332-0https://doaj.org/toc/2045-2322Abstract Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a promising approach with a high optimization potential for the treatment of peritoneal carcinomatosis. To study the efficacy of PIPAC and drugs, first rodent cancer models were developed. But inefficient drug aerosol supply and knowledge gaps concerning spatial drug distribution can limit the results based on such models. To study drug aerosol supply/deposition, computed tomography scans of a rat capnoperitoneum were used to deduce a virtual and a physical phantom of the rat capnoperitoneum (RCP). RCP qualification was performed for a specific PIPAC method, where the capnoperitoneum is continuously purged by the drug aerosol. In this context, also in-silico analyses by computational fluid dynamic modelling were conducted on the virtual RCP. The physical RCP was used for ex-vivo granulometric analyses concerning drug deposition. Results of RCP qualification show that aerosol deposition in a continuous purged rat capnoperitoneum depends strongly on the position of the inlet and outlet port. Moreover, it could be shown that the droplet size and charge condition of the drug aerosol define the deposition efficiency. In summary, the developed virtual and physical RCP enables detailed in-silico and ex-vivo analyses on drug supply/deposition in rodents.Daniel GöhlerAntje GeldnerRalf GritzkiFranz LohseStephan GroßeJulien SobiloClemens FelsmannJonathan R. BuggischAlain Le PapeAndreas RudolphMichael StintzUrs Giger-PabstNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel Göhler Antje Geldner Ralf Gritzki Franz Lohse Stephan Große Julien Sobilo Clemens Felsmann Jonathan R. Buggisch Alain Le Pape Andreas Rudolph Michael Stintz Urs Giger-Pabst Development of a rat capnoperitoneum phantom to study drug aerosol deposition in the context of anticancer research on peritoneal carcinomatosis
description	Abstract Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a promising approach with a high optimization potential for the treatment of peritoneal carcinomatosis. To study the efficacy of PIPAC and drugs, first rodent cancer models were developed. But inefficient drug aerosol supply and knowledge gaps concerning spatial drug distribution can limit the results based on such models. To study drug aerosol supply/deposition, computed tomography scans of a rat capnoperitoneum were used to deduce a virtual and a physical phantom of the rat capnoperitoneum (RCP). RCP qualification was performed for a specific PIPAC method, where the capnoperitoneum is continuously purged by the drug aerosol. In this context, also in-silico analyses by computational fluid dynamic modelling were conducted on the virtual RCP. The physical RCP was used for ex-vivo granulometric analyses concerning drug deposition. Results of RCP qualification show that aerosol deposition in a continuous purged rat capnoperitoneum depends strongly on the position of the inlet and outlet port. Moreover, it could be shown that the droplet size and charge condition of the drug aerosol define the deposition efficiency. In summary, the developed virtual and physical RCP enables detailed in-silico and ex-vivo analyses on drug supply/deposition in rodents.
format	article
author	Daniel Göhler Antje Geldner Ralf Gritzki Franz Lohse Stephan Große Julien Sobilo Clemens Felsmann Jonathan R. Buggisch Alain Le Pape Andreas Rudolph Michael Stintz Urs Giger-Pabst
author_facet	Daniel Göhler Antje Geldner Ralf Gritzki Franz Lohse Stephan Große Julien Sobilo Clemens Felsmann Jonathan R. Buggisch Alain Le Pape Andreas Rudolph Michael Stintz Urs Giger-Pabst
author_sort	Daniel Göhler
title	Development of a rat capnoperitoneum phantom to study drug aerosol deposition in the context of anticancer research on peritoneal carcinomatosis
title_short	Development of a rat capnoperitoneum phantom to study drug aerosol deposition in the context of anticancer research on peritoneal carcinomatosis
title_full	Development of a rat capnoperitoneum phantom to study drug aerosol deposition in the context of anticancer research on peritoneal carcinomatosis
title_fullStr	Development of a rat capnoperitoneum phantom to study drug aerosol deposition in the context of anticancer research on peritoneal carcinomatosis
title_full_unstemmed	Development of a rat capnoperitoneum phantom to study drug aerosol deposition in the context of anticancer research on peritoneal carcinomatosis
title_sort	development of a rat capnoperitoneum phantom to study drug aerosol deposition in the context of anticancer research on peritoneal carcinomatosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b1a0f240eea44bb2911eaa2667ca4356
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Development of a rat capnoperitoneum phantom to study drug aerosol deposition in the context of anticancer research on peritoneal carcinomatosis

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