PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression

PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression

PTEN is a lipid phosphatase that functions as a dose-dependent tumor suppressor through the PI3K/AKT pathway. Here the authors describe a signaling feedback mechanism where PTEN stability is regulated through transcriptional upregulation of X-linked ubiquitin-specific protease 11 (USP11) via the PI3...

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Detalles Bibliográficos
Autores principales: Mi Kyung Park, Yixin Yao, Weiya Xia, Stephanie Rebecca Setijono, Jae Hwan Kim, Isabelle K. Vila, Hui-Hsuan Chiu, Yun Wu, Enrique González Billalabeitia, Min Gyu Lee, Robert G. Kalb, Mien-Chie Hung, Pier Paolo Pandolfi, Su Jung Song, Min Sup Song
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/b1a406900145437995bad2a50a3a9b15
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Sumario:PTEN is a lipid phosphatase that functions as a dose-dependent tumor suppressor through the PI3K/AKT pathway. Here the authors describe a signaling feedback mechanism where PTEN stability is regulated through transcriptional upregulation of X-linked ubiquitin-specific protease 11 (USP11) via the PI3K/FOXO pathway.

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