PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression

PTEN is a lipid phosphatase that functions as a dose-dependent tumor suppressor through the PI3K/AKT pathway. Here the authors describe a signaling feedback mechanism where PTEN stability is regulated through transcriptional upregulation of X-linked ubiquitin-specific protease 11 (USP11) via the PI3...

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Autores principales:	Mi Kyung Park, Yixin Yao, Weiya Xia, Stephanie Rebecca Setijono, Jae Hwan Kim, Isabelle K. Vila, Hui-Hsuan Chiu, Yun Wu, Enrique González Billalabeitia, Min Gyu Lee, Robert G. Kalb, Mien-Chie Hung, Pier Paolo Pandolfi, Su Jung Song, Min Sup Song
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b1a406900145437995bad2a50a3a9b15
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spelling	oai:doaj.org-article:b1a406900145437995bad2a50a3a9b152021-12-02T16:58:18ZPTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression10.1038/s41467-019-08481-x2041-1723https://doaj.org/article/b1a406900145437995bad2a50a3a9b152019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08481-xhttps://doaj.org/toc/2041-1723PTEN is a lipid phosphatase that functions as a dose-dependent tumor suppressor through the PI3K/AKT pathway. Here the authors describe a signaling feedback mechanism where PTEN stability is regulated through transcriptional upregulation of X-linked ubiquitin-specific protease 11 (USP11) via the PI3K/FOXO pathway.Mi Kyung ParkYixin YaoWeiya XiaStephanie Rebecca SetijonoJae Hwan KimIsabelle K. VilaHui-Hsuan ChiuYun WuEnrique González BillalabeitiaMin Gyu LeeRobert G. KalbMien-Chie HungPier Paolo PandolfiSu Jung SongMin Sup SongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mi Kyung Park Yixin Yao Weiya Xia Stephanie Rebecca Setijono Jae Hwan Kim Isabelle K. Vila Hui-Hsuan Chiu Yun Wu Enrique González Billalabeitia Min Gyu Lee Robert G. Kalb Mien-Chie Hung Pier Paolo Pandolfi Su Jung Song Min Sup Song PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression
description	PTEN is a lipid phosphatase that functions as a dose-dependent tumor suppressor through the PI3K/AKT pathway. Here the authors describe a signaling feedback mechanism where PTEN stability is regulated through transcriptional upregulation of X-linked ubiquitin-specific protease 11 (USP11) via the PI3K/FOXO pathway.
format	article
author	Mi Kyung Park Yixin Yao Weiya Xia Stephanie Rebecca Setijono Jae Hwan Kim Isabelle K. Vila Hui-Hsuan Chiu Yun Wu Enrique González Billalabeitia Min Gyu Lee Robert G. Kalb Mien-Chie Hung Pier Paolo Pandolfi Su Jung Song Min Sup Song
author_facet	Mi Kyung Park Yixin Yao Weiya Xia Stephanie Rebecca Setijono Jae Hwan Kim Isabelle K. Vila Hui-Hsuan Chiu Yun Wu Enrique González Billalabeitia Min Gyu Lee Robert G. Kalb Mien-Chie Hung Pier Paolo Pandolfi Su Jung Song Min Sup Song
author_sort	Mi Kyung Park
title	PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression
title_short	PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression
title_full	PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression
title_fullStr	PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression
title_full_unstemmed	PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression
title_sort	pten self-regulates through usp11 via the pi3k-foxo pathway to stabilize tumor suppression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b1a406900145437995bad2a50a3a9b15
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PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression

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