Altered Brain Network Connectivity as a Potential Endophenotype of Schizophrenia

Abstract Abnormal functional brain connectivity could be considered an endophenotype of psychosis in schizophrenia. Identifying candidate endophenotypes may serve as a tool for elucidating its biological and neural mechanisms. The present study investigated the similarities and differences of featur...

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Autores principales:	Peng Li, Teng-Teng Fan, Rong-Jiang Zhao, Ying Han, Le Shi, Hong-Qiang Sun, Si-Jing Chen, Jie Shi, Xiao Lin, Lin Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b1a896830adc4387b5e32101e597b8c8
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spelling	oai:doaj.org-article:b1a896830adc4387b5e32101e597b8c82021-12-02T16:08:09ZAltered Brain Network Connectivity as a Potential Endophenotype of Schizophrenia10.1038/s41598-017-05774-32045-2322https://doaj.org/article/b1a896830adc4387b5e32101e597b8c82017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05774-3https://doaj.org/toc/2045-2322Abstract Abnormal functional brain connectivity could be considered an endophenotype of psychosis in schizophrenia. Identifying candidate endophenotypes may serve as a tool for elucidating its biological and neural mechanisms. The present study investigated the similarities and differences of features of brain network connectivity between patients and their first-degree relatives. Independent component analysis was conducted on imaging data collected from 34 healthy controls, 33 schizophrenia patients, and 30 unaffected first-degree relatives. The correlation between functional connectivity with neurocognitive performance and clinical symptoms were calculated. Abnormalities of between-network connectivity largely overlapped in patients and first-degree relatives, but the extent of such abnormalities was relatively minor in relatives. Negative connectivity between language networks and executive control networks was impaired in schizophrenia patients and their first-degree relatives, and this decreased connectivity was correlated with performance in language processing. Similar impairments were found in high-visual network and executive network coupling, and this decreased connection was correlated with the severity of positive symptoms in patients. The results indicated that abnormal functional connectivity within and between perceptual systems (i.e., high-visual and language) and executive control networks was related to the generic risk of schizophrenia, which makes it a potential endophenotype for schizophrenia.Peng LiTeng-Teng FanRong-Jiang ZhaoYing HanLe ShiHong-Qiang SunSi-Jing ChenJie ShiXiao LinLin LuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peng Li Teng-Teng Fan Rong-Jiang Zhao Ying Han Le Shi Hong-Qiang Sun Si-Jing Chen Jie Shi Xiao Lin Lin Lu Altered Brain Network Connectivity as a Potential Endophenotype of Schizophrenia
description	Abstract Abnormal functional brain connectivity could be considered an endophenotype of psychosis in schizophrenia. Identifying candidate endophenotypes may serve as a tool for elucidating its biological and neural mechanisms. The present study investigated the similarities and differences of features of brain network connectivity between patients and their first-degree relatives. Independent component analysis was conducted on imaging data collected from 34 healthy controls, 33 schizophrenia patients, and 30 unaffected first-degree relatives. The correlation between functional connectivity with neurocognitive performance and clinical symptoms were calculated. Abnormalities of between-network connectivity largely overlapped in patients and first-degree relatives, but the extent of such abnormalities was relatively minor in relatives. Negative connectivity between language networks and executive control networks was impaired in schizophrenia patients and their first-degree relatives, and this decreased connectivity was correlated with performance in language processing. Similar impairments were found in high-visual network and executive network coupling, and this decreased connection was correlated with the severity of positive symptoms in patients. The results indicated that abnormal functional connectivity within and between perceptual systems (i.e., high-visual and language) and executive control networks was related to the generic risk of schizophrenia, which makes it a potential endophenotype for schizophrenia.
format	article
author	Peng Li Teng-Teng Fan Rong-Jiang Zhao Ying Han Le Shi Hong-Qiang Sun Si-Jing Chen Jie Shi Xiao Lin Lin Lu
author_facet	Peng Li Teng-Teng Fan Rong-Jiang Zhao Ying Han Le Shi Hong-Qiang Sun Si-Jing Chen Jie Shi Xiao Lin Lin Lu
author_sort	Peng Li
title	Altered Brain Network Connectivity as a Potential Endophenotype of Schizophrenia
title_short	Altered Brain Network Connectivity as a Potential Endophenotype of Schizophrenia
title_full	Altered Brain Network Connectivity as a Potential Endophenotype of Schizophrenia
title_fullStr	Altered Brain Network Connectivity as a Potential Endophenotype of Schizophrenia
title_full_unstemmed	Altered Brain Network Connectivity as a Potential Endophenotype of Schizophrenia
title_sort	altered brain network connectivity as a potential endophenotype of schizophrenia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b1a896830adc4387b5e32101e597b8c8
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Altered Brain Network Connectivity as a Potential Endophenotype of Schizophrenia

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