Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Yuanhui Song, Yihong Li, Qien Xu, Zhe Liu Wenzhou Institute of Biomaterials and Engineering (WIBE), Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China Abstract: With the development of nanotechnology, the application of nanomaterials in the field of drug delivery h...

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Autores principales:	Song Y, Li Y, Xu Q, Liu Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b1a988c238414d5fa2e64500c94b372e
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spelling	oai:doaj.org-article:b1a988c238414d5fa2e64500c94b372e2021-12-02T00:31:19ZMesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook1178-2013https://doaj.org/article/b1a988c238414d5fa2e64500c94b372e2016-12-01T00:00:00Zhttps://www.dovepress.com/mesoporous-silica-nanoparticles-for-stimuli-responsive-controlled-drug-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yuanhui Song, Yihong Li, Qien Xu, Zhe Liu Wenzhou Institute of Biomaterials and Engineering (WIBE), Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China Abstract: With the development of nanotechnology, the application of nanomaterials in the field of drug delivery has attracted much attention in the past decades. Mesoporous silica nanoparticles as promising drug nanocarriers have become a new area of interest in recent years due to their unique properties and capabilities to efficiently entrap cargo molecules. This review describes the latest advances on the application of mesoporous silica nanoparticles in drug delivery. In particular, we focus on the stimuli-responsive controlled release systems that are able to respond to intracellular environmental changes, such as pH, ATP, GSH, enzyme, glucose, and H2O2. Moreover, drug delivery induced by exogenous stimuli including temperature, light, magnetic field, ultrasound, and electricity is also summarized. These advanced technologies demonstrate current challenges, and provide a bright future for precision diagnosis and treatment. Keywords: mesoporous silica nanoparticle, drug delivery system, controlled release, stimuli-responsive, chemotherapySong YLi YXu QLiu ZDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 87-110 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Song Y Li Y Xu Q Liu Z Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook
description	Yuanhui Song, Yihong Li, Qien Xu, Zhe Liu Wenzhou Institute of Biomaterials and Engineering (WIBE), Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China Abstract: With the development of nanotechnology, the application of nanomaterials in the field of drug delivery has attracted much attention in the past decades. Mesoporous silica nanoparticles as promising drug nanocarriers have become a new area of interest in recent years due to their unique properties and capabilities to efficiently entrap cargo molecules. This review describes the latest advances on the application of mesoporous silica nanoparticles in drug delivery. In particular, we focus on the stimuli-responsive controlled release systems that are able to respond to intracellular environmental changes, such as pH, ATP, GSH, enzyme, glucose, and H2O2. Moreover, drug delivery induced by exogenous stimuli including temperature, light, magnetic field, ultrasound, and electricity is also summarized. These advanced technologies demonstrate current challenges, and provide a bright future for precision diagnosis and treatment. Keywords: mesoporous silica nanoparticle, drug delivery system, controlled release, stimuli-responsive, chemotherapy
format	article
author	Song Y Li Y Xu Q Liu Z
author_facet	Song Y Li Y Xu Q Liu Z
author_sort	Song Y
title	Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook
title_short	Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook
title_full	Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook
title_fullStr	Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook
title_full_unstemmed	Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook
title_sort	mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/b1a988c238414d5fa2e64500c94b372e
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Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

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