Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Introduction Elevated lipid concentrations were observed in adults with headaches. However, studies in children are scarce. Recent data suggest new potential risk factors for atherosclerosis, which may be associated with headaches. The aim of the study was to analyse the blood levels of lipids and n...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Joanna Sordyl, Ilona Kopyta, Beata Sarecka-Hujar, Tomasz Francuz, Paweł Matusik, Ewa Małecka-Tendera
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2018
Materias:	children atherosclerosis dyslipidemia headache Medicine R
Acceso en línea:	https://doaj.org/article/b1a9af58326e486a861e62f7dd105a57
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b1a9af58326e486a861e62f7dd105a57
record_format	dspace
spelling	oai:doaj.org-article:b1a9af58326e486a861e62f7dd105a572021-12-02T19:15:49ZLipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report1734-19221896-915110.5114/aoms.2018.73983https://doaj.org/article/b1a9af58326e486a861e62f7dd105a572018-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Lipid-levels-and-selected-biomarkers-of-vascular-changes-in-children-with-idiopathic,81978,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Elevated lipid concentrations were observed in adults with headaches. However, studies in children are scarce. Recent data suggest new potential risk factors for atherosclerosis, which may be associated with headaches. The aim of the study was to analyse the blood levels of lipids and new markers of atherosclerosis in children with idiopathic headaches. Material and methods The study population comprised 65 children (39 with idiopathic headaches and 26 healthy children). Total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol and triacylglycerol (TG) levels were measured in every patient. Brain-derived neurotrophic factor (BDNF), soluble CD40 ligand (sCD40L), endothelial plasminogen activator inhibitor (serpin E1/PAI I) and vascular endothelial growth factor (VEGF) blood level measurements were performed in 34 children. Results Children with headaches had higher BMI z-scores (0.2 vs. –1.14; p = 0.006). TC level was lower in patients with headaches (121.04 mg/dl vs. 146.87 mg/dl, p = 0.019). No differences in concentrations of TG, HDL or LDL were found. BDNF was significantly higher in the studied group (171.57 pg/ml vs. 64.04 pg/ml, p = 0.012). The VEGF was higher in boys with headaches than in girls (368.27 pg/ml vs. 142.86 pg/ml, p = 0.011). There were no differences in levels of VEGF, sCD40L or PAI-1 between groups. Conclusions Children with headaches have lower total cholesterol and higher BDNF levels than controls. No significant difference in levels of triacylglycerols, HDL cholesterol, LDL cholesterol, VEGF, sCD40L or PAI-1 was found between children with headaches and controls.Joanna SordylIlona KopytaBeata Sarecka-HujarTomasz FrancuzPaweł MatusikEwa Małecka-TenderaTermedia Publishing HousearticlechildrenatherosclerosisdyslipidemiaheadacheMedicineRENArchives of Medical Science, Vol 15, Iss 1, Pp 120-125 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	children atherosclerosis dyslipidemia headache Medicine R
spellingShingle	children atherosclerosis dyslipidemia headache Medicine R Joanna Sordyl Ilona Kopyta Beata Sarecka-Hujar Tomasz Francuz Paweł Matusik Ewa Małecka-Tendera Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report
description	Introduction Elevated lipid concentrations were observed in adults with headaches. However, studies in children are scarce. Recent data suggest new potential risk factors for atherosclerosis, which may be associated with headaches. The aim of the study was to analyse the blood levels of lipids and new markers of atherosclerosis in children with idiopathic headaches. Material and methods The study population comprised 65 children (39 with idiopathic headaches and 26 healthy children). Total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol and triacylglycerol (TG) levels were measured in every patient. Brain-derived neurotrophic factor (BDNF), soluble CD40 ligand (sCD40L), endothelial plasminogen activator inhibitor (serpin E1/PAI I) and vascular endothelial growth factor (VEGF) blood level measurements were performed in 34 children. Results Children with headaches had higher BMI z-scores (0.2 vs. –1.14; p = 0.006). TC level was lower in patients with headaches (121.04 mg/dl vs. 146.87 mg/dl, p = 0.019). No differences in concentrations of TG, HDL or LDL were found. BDNF was significantly higher in the studied group (171.57 pg/ml vs. 64.04 pg/ml, p = 0.012). The VEGF was higher in boys with headaches than in girls (368.27 pg/ml vs. 142.86 pg/ml, p = 0.011). There were no differences in levels of VEGF, sCD40L or PAI-1 between groups. Conclusions Children with headaches have lower total cholesterol and higher BDNF levels than controls. No significant difference in levels of triacylglycerols, HDL cholesterol, LDL cholesterol, VEGF, sCD40L or PAI-1 was found between children with headaches and controls.
format	article
author	Joanna Sordyl Ilona Kopyta Beata Sarecka-Hujar Tomasz Francuz Paweł Matusik Ewa Małecka-Tendera
author_facet	Joanna Sordyl Ilona Kopyta Beata Sarecka-Hujar Tomasz Francuz Paweł Matusik Ewa Małecka-Tendera
author_sort	Joanna Sordyl
title	Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report
title_short	Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report
title_full	Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report
title_fullStr	Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report
title_full_unstemmed	Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report
title_sort	lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report
publisher	Termedia Publishing House
publishDate	2018
url	https://doaj.org/article/b1a9af58326e486a861e62f7dd105a57
work_keys_str_mv	AT joannasordyl lipidlevelsandselectedbiomarkersofvascularchangesinchildrenwithidiopathicheadachesapreliminaryreport AT ilonakopyta lipidlevelsandselectedbiomarkersofvascularchangesinchildrenwithidiopathicheadachesapreliminaryreport AT beatasareckahujar lipidlevelsandselectedbiomarkersofvascularchangesinchildrenwithidiopathicheadachesapreliminaryreport AT tomaszfrancuz lipidlevelsandselectedbiomarkersofvascularchangesinchildrenwithidiopathicheadachesapreliminaryreport AT pawełmatusik lipidlevelsandselectedbiomarkersofvascularchangesinchildrenwithidiopathicheadachesapreliminaryreport AT ewamałeckatendera lipidlevelsandselectedbiomarkersofvascularchangesinchildrenwithidiopathicheadachesapreliminaryreport
_version_	1718376992011714560

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Ejemplares similares