An amber obligate active site-directed ligand evolution technique for phage display

Most epigenetic regulator inhibitors target tunnels of active sites, rather than the peptide binding groove, leading to concerns with low selectivity. Here the authors use an amber obligate phage library to rapidly identify isoform-selective inhibitors of SIRT2.

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Autores principales:	Jeffery M. Tharp, J. Trae Hampton, Catrina A. Reed, Andreas Ehnbom, Peng-Hsun Chase Chen, Jared S. Morse, Yadagirri Kurra, Lisa M. Pérez, Shiqing Xu, Wenshe Ray Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b1aac1c05c7c4fed851748bbcd7bc307
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spelling	oai:doaj.org-article:b1aac1c05c7c4fed851748bbcd7bc3072021-12-02T16:56:31ZAn amber obligate active site-directed ligand evolution technique for phage display10.1038/s41467-020-15057-72041-1723https://doaj.org/article/b1aac1c05c7c4fed851748bbcd7bc3072020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15057-7https://doaj.org/toc/2041-1723Most epigenetic regulator inhibitors target tunnels of active sites, rather than the peptide binding groove, leading to concerns with low selectivity. Here the authors use an amber obligate phage library to rapidly identify isoform-selective inhibitors of SIRT2.Jeffery M. TharpJ. Trae HamptonCatrina A. ReedAndreas EhnbomPeng-Hsun Chase ChenJared S. MorseYadagirri KurraLisa M. PérezShiqing XuWenshe Ray LiuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jeffery M. Tharp J. Trae Hampton Catrina A. Reed Andreas Ehnbom Peng-Hsun Chase Chen Jared S. Morse Yadagirri Kurra Lisa M. Pérez Shiqing Xu Wenshe Ray Liu An amber obligate active site-directed ligand evolution technique for phage display
description	Most epigenetic regulator inhibitors target tunnels of active sites, rather than the peptide binding groove, leading to concerns with low selectivity. Here the authors use an amber obligate phage library to rapidly identify isoform-selective inhibitors of SIRT2.
format	article
author	Jeffery M. Tharp J. Trae Hampton Catrina A. Reed Andreas Ehnbom Peng-Hsun Chase Chen Jared S. Morse Yadagirri Kurra Lisa M. Pérez Shiqing Xu Wenshe Ray Liu
author_facet	Jeffery M. Tharp J. Trae Hampton Catrina A. Reed Andreas Ehnbom Peng-Hsun Chase Chen Jared S. Morse Yadagirri Kurra Lisa M. Pérez Shiqing Xu Wenshe Ray Liu
author_sort	Jeffery M. Tharp
title	An amber obligate active site-directed ligand evolution technique for phage display
title_short	An amber obligate active site-directed ligand evolution technique for phage display
title_full	An amber obligate active site-directed ligand evolution technique for phage display
title_fullStr	An amber obligate active site-directed ligand evolution technique for phage display
title_full_unstemmed	An amber obligate active site-directed ligand evolution technique for phage display
title_sort	amber obligate active site-directed ligand evolution technique for phage display
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b1aac1c05c7c4fed851748bbcd7bc307
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An amber obligate active site-directed ligand evolution technique for phage display

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