Novel Cellulose Acetate-Based Monophasic Hybrid Membranes for Improved Blood Purification Devices: Characterization under Dynamic Conditions
A novel cellulose acetate-based monophasic hybrid skinned amine-functionalized CA-SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>NH<sub>2</sub> membrane was synthesized using an innovative method which combines the phase inversion and sol-gel techniques....
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/b1ab1cc4707f4a8d89872be1ba51e63a |
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| Sumario: | A novel cellulose acetate-based monophasic hybrid skinned amine-functionalized CA-SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>NH<sub>2</sub> membrane was synthesized using an innovative method which combines the phase inversion and sol-gel techniques. Morphological characterization was performed by scanning electron microscopy (SEM), and the chemical composition was analyzed by Fourier transform infrared spectroscopy in attenuated total reflection mode (ATR-FTIR). The characterization of the monophasic hybrid CA-SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>NH<sub>2</sub> membrane in terms of permeation properties was carried out in an in-house-built single hemodialysis membrane module (SHDMM) under dynamic conditions. Permeation experiments were performed to determine the hydraulic permeability (Lp), molecular weight cut-off (MWCO) and the rejection coefficients to urea, creatinine, uric acid, and albumin. SEM confirmed the existence of a very thin (<1 µm) top dense layer and a much thicker bottom porous surface, and ATR-FTIR showed the main bands belonging to the CA-based membranes. Permeation studies revealed that the Lp and MWCO of the CA-SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>NH<sub>2</sub> membrane were 66.61 kg·h<sup>−1</sup>·m<sup>−2</sup>·bar<sup>−1</sup> and 24.5 kDa, respectively, and that the Lp was 1.8 times higher compared to a pure CA membrane. Furthermore, the CA-SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>NH<sub>2</sub> membrane fully permeated urea, creatinine, and uric acid while completely retaining albumin. Long-term filtration studies of albumin solutions indicated that fouling does not occur at the surface of the CA-SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>NH<sub>2</sub> membrane. |
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