Novel Cellulose Acetate-Based Monophasic Hybrid Membranes for Improved Blood Purification Devices: Characterization under Dynamic Conditions

A novel cellulose acetate-based monophasic hybrid skinned amine-functionalized CA-SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>NH<sub>2</sub> membrane was synthesized using an innovative method which combines the phase inversion and sol-gel techniques....

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Autores principales: Adriana Janeca, Flávia S. C. Rodrigues, Maria Clara Gonçalves, Mónica Faria
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Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/b1ab1cc4707f4a8d89872be1ba51e63a
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spelling oai:doaj.org-article:b1ab1cc4707f4a8d89872be1ba51e63a2021-11-25T18:19:37ZNovel Cellulose Acetate-Based Monophasic Hybrid Membranes for Improved Blood Purification Devices: Characterization under Dynamic Conditions10.3390/membranes111108252077-0375https://doaj.org/article/b1ab1cc4707f4a8d89872be1ba51e63a2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0375/11/11/825https://doaj.org/toc/2077-0375A novel cellulose acetate-based monophasic hybrid skinned amine-functionalized CA-SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>NH<sub>2</sub> membrane was synthesized using an innovative method which combines the phase inversion and sol-gel techniques. Morphological characterization was performed by scanning electron microscopy (SEM), and the chemical composition was analyzed by Fourier transform infrared spectroscopy in attenuated total reflection mode (ATR-FTIR). The characterization of the monophasic hybrid CA-SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>NH<sub>2</sub> membrane in terms of permeation properties was carried out in an in-house-built single hemodialysis membrane module (SHDMM) under dynamic conditions. Permeation experiments were performed to determine the hydraulic permeability (Lp), molecular weight cut-off (MWCO) and the rejection coefficients to urea, creatinine, uric acid, and albumin. SEM confirmed the existence of a very thin (<1 µm) top dense layer and a much thicker bottom porous surface, and ATR-FTIR showed the main bands belonging to the CA-based membranes. Permeation studies revealed that the Lp and MWCO of the CA-SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>NH<sub>2</sub> membrane were 66.61 kg·h<sup>−1</sup>·m<sup>−2</sup>·bar<sup>−1</sup> and 24.5 kDa, respectively, and that the Lp was 1.8 times higher compared to a pure CA membrane. Furthermore, the CA-SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>NH<sub>2</sub> membrane fully permeated urea, creatinine, and uric acid while completely retaining albumin. Long-term filtration studies of albumin solutions indicated that fouling does not occur at the surface of the CA-SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>NH<sub>2</sub> membrane.Adriana JanecaFlávia S. C. RodriguesMaria Clara GonçalvesMónica FariaMDPI AGarticlemonophasic hybrid membranesol-gelphase inversionblood purificationultrafiltrationcrossflow filtrationChemical technologyTP1-1185Chemical engineeringTP155-156ENMembranes, Vol 11, Iss 825, p 825 (2021)
institution DOAJ
collection DOAJ
language EN
topic monophasic hybrid membrane
sol-gel
phase inversion
blood purification
ultrafiltration
crossflow filtration
Chemical technology
TP1-1185
Chemical engineering
TP155-156
spellingShingle monophasic hybrid membrane
sol-gel
phase inversion
blood purification
ultrafiltration
crossflow filtration
Chemical technology
TP1-1185
Chemical engineering
TP155-156
Adriana Janeca
Flávia S. C. Rodrigues
Maria Clara Gonçalves
Mónica Faria
Novel Cellulose Acetate-Based Monophasic Hybrid Membranes for Improved Blood Purification Devices: Characterization under Dynamic Conditions
description A novel cellulose acetate-based monophasic hybrid skinned amine-functionalized CA-SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>NH<sub>2</sub> membrane was synthesized using an innovative method which combines the phase inversion and sol-gel techniques. Morphological characterization was performed by scanning electron microscopy (SEM), and the chemical composition was analyzed by Fourier transform infrared spectroscopy in attenuated total reflection mode (ATR-FTIR). The characterization of the monophasic hybrid CA-SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>NH<sub>2</sub> membrane in terms of permeation properties was carried out in an in-house-built single hemodialysis membrane module (SHDMM) under dynamic conditions. Permeation experiments were performed to determine the hydraulic permeability (Lp), molecular weight cut-off (MWCO) and the rejection coefficients to urea, creatinine, uric acid, and albumin. SEM confirmed the existence of a very thin (<1 µm) top dense layer and a much thicker bottom porous surface, and ATR-FTIR showed the main bands belonging to the CA-based membranes. Permeation studies revealed that the Lp and MWCO of the CA-SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>NH<sub>2</sub> membrane were 66.61 kg·h<sup>−1</sup>·m<sup>−2</sup>·bar<sup>−1</sup> and 24.5 kDa, respectively, and that the Lp was 1.8 times higher compared to a pure CA membrane. Furthermore, the CA-SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>NH<sub>2</sub> membrane fully permeated urea, creatinine, and uric acid while completely retaining albumin. Long-term filtration studies of albumin solutions indicated that fouling does not occur at the surface of the CA-SiO<sub>2</sub>-(CH<sub>2</sub>)<sub>3</sub>NH<sub>2</sub> membrane.
format article
author Adriana Janeca
Flávia S. C. Rodrigues
Maria Clara Gonçalves
Mónica Faria
author_facet Adriana Janeca
Flávia S. C. Rodrigues
Maria Clara Gonçalves
Mónica Faria
author_sort Adriana Janeca
title Novel Cellulose Acetate-Based Monophasic Hybrid Membranes for Improved Blood Purification Devices: Characterization under Dynamic Conditions
title_short Novel Cellulose Acetate-Based Monophasic Hybrid Membranes for Improved Blood Purification Devices: Characterization under Dynamic Conditions
title_full Novel Cellulose Acetate-Based Monophasic Hybrid Membranes for Improved Blood Purification Devices: Characterization under Dynamic Conditions
title_fullStr Novel Cellulose Acetate-Based Monophasic Hybrid Membranes for Improved Blood Purification Devices: Characterization under Dynamic Conditions
title_full_unstemmed Novel Cellulose Acetate-Based Monophasic Hybrid Membranes for Improved Blood Purification Devices: Characterization under Dynamic Conditions
title_sort novel cellulose acetate-based monophasic hybrid membranes for improved blood purification devices: characterization under dynamic conditions
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/b1ab1cc4707f4a8d89872be1ba51e63a
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AT mariaclaragoncalves novelcelluloseacetatebasedmonophasichybridmembranesforimprovedbloodpurificationdevicescharacterizationunderdynamicconditions
AT monicafaria novelcelluloseacetatebasedmonophasichybridmembranesforimprovedbloodpurificationdevicescharacterizationunderdynamicconditions
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