Metabolism and obesity: role of leptin receptor gene

Background. Currently more than 119 obesity-related polymorphisms is known to participate in adult obesity. One of them is LEPR Q223R. Many researches shown association of this polymorphism with adult obesity. However, the role of LEPR Q223R in adolescent overweight and obesity is the matter of disp...

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Autores principales:	K. D. Ievleva, T. A. Bairova, L. V. Rychkova, E. A. Sheneman, E. E. Khramova, L. I. Kolesnikova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	lepr q223r obesity overweight adolescents Science Q
Acceso en línea:	https://doaj.org/article/b1aecff101c9497f955683def39e18f2
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spelling	oai:doaj.org-article:b1aecff101c9497f955683def39e18f22021-11-23T06:14:38ZMetabolism and obesity: role of leptin receptor gene2541-94202587-959610.12737/article_59e85cb55584e4.51145791https://doaj.org/article/b1aecff101c9497f955683def39e18f22017-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/433https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Currently more than 119 obesity-related polymorphisms is known to participate in adult obesity. One of them is LEPR Q223R. Many researches shown association of this polymorphism with adult obesity. However, the role of LEPR Q223R in adolescent overweight and obesity is the matter of dispute. Aim: to determine association of polymorphism Q223R of LEPR gene with some biochemical and hormonal measurements of blood in female adolescents with normal weight and with overweight and obesity. Materials and methods. A total of 103 female adolescents (14-17 years of age) was examined. All girls were divided into 2 groups: 43 girls with normal weight (SDS BM 10.311 ± 0.585), and 65 girls with overweight and obesity (SDS BMI 2.255± 0.739) (р < 0.0001). Height, weight, BM1, SDS BM1 were measured. Laboratory tests included triglycerides, total cholesterol and its fraction, TTH, free thyroxin and leptin. All girls were genotyped on carrier of LEPR Q223R. Statistical analysis was provided by software Statistica 8.0 using nonparametric Mann - Whitney methods and Chi-square test with Yates correction. Results. Significant association of carrying RR-genotype with increase of SDS BM1 (p = 0.006), THS (p = 0.006) and decrease of free thyroxin was shown in control group. Conclusion. Our results showed the association of R-allele with increase of SDS BM1, THS and decrease T4 free in control group.K. D. IevlevaT. A. BairovaL. V. RychkovaE. A. ShenemanE. E. KhramovaL. I. KolesnikovaScientific Сentre for Family Health and Human Reproduction Problemsarticlelepr q223robesityoverweightadolescentslepr q223rScienceQRUActa Biomedica Scientifica, Vol 2, Iss 5(1), Pp 56-62 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	lepr q223r obesity overweight adolescents lepr q223r Science Q
spellingShingle	lepr q223r obesity overweight adolescents lepr q223r Science Q K. D. Ievleva T. A. Bairova L. V. Rychkova E. A. Sheneman E. E. Khramova L. I. Kolesnikova Metabolism and obesity: role of leptin receptor gene
description	Background. Currently more than 119 obesity-related polymorphisms is known to participate in adult obesity. One of them is LEPR Q223R. Many researches shown association of this polymorphism with adult obesity. However, the role of LEPR Q223R in adolescent overweight and obesity is the matter of dispute. Aim: to determine association of polymorphism Q223R of LEPR gene with some biochemical and hormonal measurements of blood in female adolescents with normal weight and with overweight and obesity. Materials and methods. A total of 103 female adolescents (14-17 years of age) was examined. All girls were divided into 2 groups: 43 girls with normal weight (SDS BM 10.311 ± 0.585), and 65 girls with overweight and obesity (SDS BMI 2.255± 0.739) (р < 0.0001). Height, weight, BM1, SDS BM1 were measured. Laboratory tests included triglycerides, total cholesterol and its fraction, TTH, free thyroxin and leptin. All girls were genotyped on carrier of LEPR Q223R. Statistical analysis was provided by software Statistica 8.0 using nonparametric Mann - Whitney methods and Chi-square test with Yates correction. Results. Significant association of carrying RR-genotype with increase of SDS BM1 (p = 0.006), THS (p = 0.006) and decrease of free thyroxin was shown in control group. Conclusion. Our results showed the association of R-allele with increase of SDS BM1, THS and decrease T4 free in control group.
format	article
author	K. D. Ievleva T. A. Bairova L. V. Rychkova E. A. Sheneman E. E. Khramova L. I. Kolesnikova
author_facet	K. D. Ievleva T. A. Bairova L. V. Rychkova E. A. Sheneman E. E. Khramova L. I. Kolesnikova
author_sort	K. D. Ievleva
title	Metabolism and obesity: role of leptin receptor gene
title_short	Metabolism and obesity: role of leptin receptor gene
title_full	Metabolism and obesity: role of leptin receptor gene
title_fullStr	Metabolism and obesity: role of leptin receptor gene
title_full_unstemmed	Metabolism and obesity: role of leptin receptor gene
title_sort	metabolism and obesity: role of leptin receptor gene
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/b1aecff101c9497f955683def39e18f2
work_keys_str_mv	AT kdievleva metabolismandobesityroleofleptinreceptorgene AT tabairova metabolismandobesityroleofleptinreceptorgene AT lvrychkova metabolismandobesityroleofleptinreceptorgene AT easheneman metabolismandobesityroleofleptinreceptorgene AT eekhramova metabolismandobesityroleofleptinreceptorgene AT likolesnikova metabolismandobesityroleofleptinreceptorgene
_version_	1718417027595501568

Metabolism and obesity: role of leptin receptor gene

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