Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop

Loss of Nestin sensitizes non-small cell lung carcinoma (NSCLC) to oxidative stress. Here, the authors report a feedback loop between Nestin and Nrf2 wherein Nestin competes with Nrf2 for Keap1 binding, preventing Nrf2 degradation, and show the Nestin–Keap1–Nrf2 axis to regulate redox homeostasis in...

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Autores principales:	Jiancheng Wang, Qiying Lu, Jianye Cai, Yi Wang, Xiaofan Lai, Yuan Qiu, Yinong Huang, Qiong Ke, Yanan Zhang, Yuanjun Guan, Haoxiang Wu, Yuanyuan Wang, Xin Liu, Yue Shi, Kang Zhang, Maosheng Wang, Andy Peng Xiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b1b00c42536b4061b50abe0984df2505
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:b1b00c42536b4061b50abe0984df25052021-12-02T16:57:32ZNestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop10.1038/s41467-019-12925-92041-1723https://doaj.org/article/b1b00c42536b4061b50abe0984df25052019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12925-9https://doaj.org/toc/2041-1723Loss of Nestin sensitizes non-small cell lung carcinoma (NSCLC) to oxidative stress. Here, the authors report a feedback loop between Nestin and Nrf2 wherein Nestin competes with Nrf2 for Keap1 binding, preventing Nrf2 degradation, and show the Nestin–Keap1–Nrf2 axis to regulate redox homeostasis in NSCLC.Jiancheng WangQiying LuJianye CaiYi WangXiaofan LaiYuan QiuYinong HuangQiong KeYanan ZhangYuanjun GuanHaoxiang WuYuanyuan WangXin LiuYue ShiKang ZhangMaosheng WangAndy Peng XiangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiancheng Wang Qiying Lu Jianye Cai Yi Wang Xiaofan Lai Yuan Qiu Yinong Huang Qiong Ke Yanan Zhang Yuanjun Guan Haoxiang Wu Yuanyuan Wang Xin Liu Yue Shi Kang Zhang Maosheng Wang Andy Peng Xiang Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop
description	Loss of Nestin sensitizes non-small cell lung carcinoma (NSCLC) to oxidative stress. Here, the authors report a feedback loop between Nestin and Nrf2 wherein Nestin competes with Nrf2 for Keap1 binding, preventing Nrf2 degradation, and show the Nestin–Keap1–Nrf2 axis to regulate redox homeostasis in NSCLC.
format	article
author	Jiancheng Wang Qiying Lu Jianye Cai Yi Wang Xiaofan Lai Yuan Qiu Yinong Huang Qiong Ke Yanan Zhang Yuanjun Guan Haoxiang Wu Yuanyuan Wang Xin Liu Yue Shi Kang Zhang Maosheng Wang Andy Peng Xiang
author_facet	Jiancheng Wang Qiying Lu Jianye Cai Yi Wang Xiaofan Lai Yuan Qiu Yinong Huang Qiong Ke Yanan Zhang Yuanjun Guan Haoxiang Wu Yuanyuan Wang Xin Liu Yue Shi Kang Zhang Maosheng Wang Andy Peng Xiang
author_sort	Jiancheng Wang
title	Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop
title_short	Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop
title_full	Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop
title_fullStr	Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop
title_full_unstemmed	Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop
title_sort	nestin regulates cellular redox homeostasis in lung cancer through the keap1–nrf2 feedback loop
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b1b00c42536b4061b50abe0984df2505
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Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop

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