Plasma osteopontin as a biomarker of Alzheimer’s disease and vascular cognitive impairment

Abstract Cerebrovascular disease (CeVD) and neurodegenerative dementia such as Alzheimer’s disease (AD) are frequently associated comorbidities in the elderly, sharing common risk factors and pathophysiological mechanisms including neuroinflammation. Osteopontin (OPN) is an inflammatory marker found...

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Autores principales:	Yuek Ling Chai, Joyce R. Chong, Ainiah R. Raquib, Xin Xu, Saima Hilal, Narayanaswamy Venketasubramanian, Boon Yeow Tan, Alan P. Kumar, Gautam Sethi, Christopher P. Chen, Mitchell K. P. Lai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b1b12e90137f45e5a30c6c0e5d07ecd7
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spelling	oai:doaj.org-article:b1b12e90137f45e5a30c6c0e5d07ecd72021-12-02T14:21:59ZPlasma osteopontin as a biomarker of Alzheimer’s disease and vascular cognitive impairment10.1038/s41598-021-83601-62045-2322https://doaj.org/article/b1b12e90137f45e5a30c6c0e5d07ecd72021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83601-6https://doaj.org/toc/2045-2322Abstract Cerebrovascular disease (CeVD) and neurodegenerative dementia such as Alzheimer’s disease (AD) are frequently associated comorbidities in the elderly, sharing common risk factors and pathophysiological mechanisms including neuroinflammation. Osteopontin (OPN) is an inflammatory marker found upregulated in vascular diseases as well as in AD. However, its involvement in vascular dementia (VaD) and pre-dementia stages, namely cognitive impairment no dementia (CIND), both of which fall under the spectrum of vascular cognitive impairment (VCI), has yet to be examined. Its correlations with inflammatory cytokines in cognitive impairment also await investigation. 80 subjects with no cognitive impairment (NCI), 160 with CIND and 144 with dementia were included in a cross-sectional study on a Singapore-based memory clinic cohort. All subjects underwent comprehensive clinical, neuropsychological and brain neuroimaging assessments, together with clinical diagnoses based on established criteria. Blood samples were collected and OPN as well as inflammatory cytokines interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF) were measured using immunoassays. Multivariate regression analyses showed significant associations between increased OPN and VCI groups, namely CIND with CeVD, AD with CeVD and VaD. Interestingly, higher OPN was also significantly associated with AD even in the absence of CeVD. We further showed that increased OPN significantly associated with neuroimaging markers of CeVD and neurodegeneration, including cortical infarcts, lacunes, white matter hyperintensities and brain atrophy. OPN also correlated with elevated levels of IL-6, IL-8 and TNF. Our findings suggest that OPN may play a role in both VCI and neurodegenerative dementias. Further longitudinal analyses are needed to assess the prognostic utility of OPN in disease prediction and monitoring.Yuek Ling ChaiJoyce R. ChongAiniah R. RaquibXin XuSaima HilalNarayanaswamy VenketasubramanianBoon Yeow TanAlan P. KumarGautam SethiChristopher P. ChenMitchell K. P. LaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuek Ling Chai Joyce R. Chong Ainiah R. Raquib Xin Xu Saima Hilal Narayanaswamy Venketasubramanian Boon Yeow Tan Alan P. Kumar Gautam Sethi Christopher P. Chen Mitchell K. P. Lai Plasma osteopontin as a biomarker of Alzheimer’s disease and vascular cognitive impairment
description	Abstract Cerebrovascular disease (CeVD) and neurodegenerative dementia such as Alzheimer’s disease (AD) are frequently associated comorbidities in the elderly, sharing common risk factors and pathophysiological mechanisms including neuroinflammation. Osteopontin (OPN) is an inflammatory marker found upregulated in vascular diseases as well as in AD. However, its involvement in vascular dementia (VaD) and pre-dementia stages, namely cognitive impairment no dementia (CIND), both of which fall under the spectrum of vascular cognitive impairment (VCI), has yet to be examined. Its correlations with inflammatory cytokines in cognitive impairment also await investigation. 80 subjects with no cognitive impairment (NCI), 160 with CIND and 144 with dementia were included in a cross-sectional study on a Singapore-based memory clinic cohort. All subjects underwent comprehensive clinical, neuropsychological and brain neuroimaging assessments, together with clinical diagnoses based on established criteria. Blood samples were collected and OPN as well as inflammatory cytokines interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF) were measured using immunoassays. Multivariate regression analyses showed significant associations between increased OPN and VCI groups, namely CIND with CeVD, AD with CeVD and VaD. Interestingly, higher OPN was also significantly associated with AD even in the absence of CeVD. We further showed that increased OPN significantly associated with neuroimaging markers of CeVD and neurodegeneration, including cortical infarcts, lacunes, white matter hyperintensities and brain atrophy. OPN also correlated with elevated levels of IL-6, IL-8 and TNF. Our findings suggest that OPN may play a role in both VCI and neurodegenerative dementias. Further longitudinal analyses are needed to assess the prognostic utility of OPN in disease prediction and monitoring.
format	article
author	Yuek Ling Chai Joyce R. Chong Ainiah R. Raquib Xin Xu Saima Hilal Narayanaswamy Venketasubramanian Boon Yeow Tan Alan P. Kumar Gautam Sethi Christopher P. Chen Mitchell K. P. Lai
author_facet	Yuek Ling Chai Joyce R. Chong Ainiah R. Raquib Xin Xu Saima Hilal Narayanaswamy Venketasubramanian Boon Yeow Tan Alan P. Kumar Gautam Sethi Christopher P. Chen Mitchell K. P. Lai
author_sort	Yuek Ling Chai
title	Plasma osteopontin as a biomarker of Alzheimer’s disease and vascular cognitive impairment
title_short	Plasma osteopontin as a biomarker of Alzheimer’s disease and vascular cognitive impairment
title_full	Plasma osteopontin as a biomarker of Alzheimer’s disease and vascular cognitive impairment
title_fullStr	Plasma osteopontin as a biomarker of Alzheimer’s disease and vascular cognitive impairment
title_full_unstemmed	Plasma osteopontin as a biomarker of Alzheimer’s disease and vascular cognitive impairment
title_sort	plasma osteopontin as a biomarker of alzheimer’s disease and vascular cognitive impairment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b1b12e90137f45e5a30c6c0e5d07ecd7
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Plasma osteopontin as a biomarker of Alzheimer’s disease and vascular cognitive impairment

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