Discovery of the <named-content content-type="genus-species">Pseudomonas</named-content> Polyyne Protegencin by a Phylogeny-Guided Study of Polyyne Biosynthetic Gene Cluster Diversity

Discovery of the <named-content content-type="genus-species">Pseudomonas</named-content> Polyyne Protegencin by a Phylogeny-Guided Study of Polyyne Biosynthetic Gene Cluster Diversity

ABSTRACT Natural products that possess alkyne or polyyne moieties have been isolated from a variety of biological sources and possess a broad a range of bioactivities. In bacteria, the basic biosynthesis of polyynes is known, but their biosynthetic gene cluster (BGC) distribution and evolutionary re...

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Bibliographic Details
Main Authors: Alex J. Mullins, Gordon Webster, Hak Joong Kim, Jinlian Zhao, Yoana D. Petrova, Christina E. Ramming, Matthew Jenner, James A. H. Murray, Thomas R. Connor, Christian Hertweck, Gregory L. Challis, Eshwar Mahenthiralingam
Format: article
Language:EN
Published: American Society for Microbiology 2021
Subjects:
Pseudomonas
biosynthetic gene clusters
natural products
phylogenetics
polyynes
Microbiology
QR1-502
Online Access:https://doaj.org/article/b1b4253ed1464c9da85b6b1a1b4667c8
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